tetano
Editor, Senior Moderator
J Med Cases
. 2022 Apr;13(4):168-171.
doi: 10.14740/jmc3886. Epub 2022 Mar 25.
COVID-19 Presenting With a Challenging Combination of Thrombocytopenia and Thrombosis
Swapna Ravi[SUP] 1 [/SUP], Sushmita Khadka[SUP] 2 [/SUP], Charumathi Subrahmanian Raghu[SUP] 3 [/SUP], Ananth Ravi[SUP] 4 [/SUP], Sharmisha Vanukuri[SUP] 5 [/SUP], Tapasya Mandalapu[SUP] 6 [/SUP], Vineela Kasireddy[SUP] 7 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) causes various hematological abnormalities, leading to several complications in the disease course. We report two COVID-19 cases presenting with a combination of thrombocytopenia and coagulopathy complications in late 2020. A 73-year-old male with a history of immune thrombocytopenic purpura (ITP) presented with acute ischemic stroke and acute thrombocytopenia in the setting of COVID-19. He was managed with steroids and intravenous immunoglobulin (IVIG) and had a subsequent acute ischemic stroke with microhemorrhages. Another 72-year-old female with a history of cryptogenic liver cirrhosis and chronic thrombocytopenia presenting with acute thrombocytopenia in the setting of COVID-19 was managed with steroids and IVIG. She had a coagulopathic complication of deep venous thrombosis (DVT) later in her disease course managed with inferior vena cava filter and low-dose enoxaparin, but she subsequently died with a bleeding complication of retroperitoneal hemorrhage. Despite the aggressive ongoing research, the treatment options for severe COVID-19 are limited to date and the mortality remains high. Both these cases are examples of challenging situations that the physicians are currently facing with COVID-19 pandemic.
Keywords: COVID-19; Coagulopathy; Thrombocytopenia; Thrombosis.
. 2022 Apr;13(4):168-171.
doi: 10.14740/jmc3886. Epub 2022 Mar 25.
COVID-19 Presenting With a Challenging Combination of Thrombocytopenia and Thrombosis
Swapna Ravi[SUP] 1 [/SUP], Sushmita Khadka[SUP] 2 [/SUP], Charumathi Subrahmanian Raghu[SUP] 3 [/SUP], Ananth Ravi[SUP] 4 [/SUP], Sharmisha Vanukuri[SUP] 5 [/SUP], Tapasya Mandalapu[SUP] 6 [/SUP], Vineela Kasireddy[SUP] 7 [/SUP]
Affiliations
- PMID: 35464331
- PMCID: PMC8993441
- DOI: 10.14740/jmc3886
Abstract
Coronavirus disease 2019 (COVID-19) causes various hematological abnormalities, leading to several complications in the disease course. We report two COVID-19 cases presenting with a combination of thrombocytopenia and coagulopathy complications in late 2020. A 73-year-old male with a history of immune thrombocytopenic purpura (ITP) presented with acute ischemic stroke and acute thrombocytopenia in the setting of COVID-19. He was managed with steroids and intravenous immunoglobulin (IVIG) and had a subsequent acute ischemic stroke with microhemorrhages. Another 72-year-old female with a history of cryptogenic liver cirrhosis and chronic thrombocytopenia presenting with acute thrombocytopenia in the setting of COVID-19 was managed with steroids and IVIG. She had a coagulopathic complication of deep venous thrombosis (DVT) later in her disease course managed with inferior vena cava filter and low-dose enoxaparin, but she subsequently died with a bleeding complication of retroperitoneal hemorrhage. Despite the aggressive ongoing research, the treatment options for severe COVID-19 are limited to date and the mortality remains high. Both these cases are examples of challenging situations that the physicians are currently facing with COVID-19 pandemic.
Keywords: COVID-19; Coagulopathy; Thrombocytopenia; Thrombosis.