tetano
Editor, Senior Moderator
J Med Cases
. 2020 Jun;11(6):166-168.
doi: 10.14740/jmc3481. Epub 2020 May 28.
SARS-CoV-2-Induced Severe Immune Thrombocytopenic Purpura
Aurelien Gonze[SUP] 1 [/SUP], Colin Hannesse[SUP] 1 [/SUP], Nathalie Coppens[SUP] 1 [/SUP], Helene Vellemans[SUP] 2 [/SUP], Gisele Maury[SUP] 1 [/SUP]
Affiliations
Abstract
Hematologic changes are common in coronavirus infections, including lymphopenia and thrombocytopenia. Thrombocytopenia was frequent during the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 - 2003. The mechanisms involved in platelet deficiency are unclear. Many viruses are known to trigger immune thrombocytopenic purpura (ITP), but the disease is rarely described in association with coronavirus. We describe the case of acute ITP associated with coronavirus disease 19 (COVID-19) in an 86-year-old woman. Intravenous gamma-globulin and corticosteroids were effective on platelet count evolution.
Keywords: COVID-19; Coronavirus; Corticosteroids; Gamma-globulin; Immune; Thrombocytopenic purpura.
. 2020 Jun;11(6):166-168.
doi: 10.14740/jmc3481. Epub 2020 May 28.
SARS-CoV-2-Induced Severe Immune Thrombocytopenic Purpura
Aurelien Gonze[SUP] 1 [/SUP], Colin Hannesse[SUP] 1 [/SUP], Nathalie Coppens[SUP] 1 [/SUP], Helene Vellemans[SUP] 2 [/SUP], Gisele Maury[SUP] 1 [/SUP]
Affiliations
- PMID: 33984082
- PMCID: PMC8040431
- DOI: 10.14740/jmc3481
Abstract
Hematologic changes are common in coronavirus infections, including lymphopenia and thrombocytopenia. Thrombocytopenia was frequent during the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 - 2003. The mechanisms involved in platelet deficiency are unclear. Many viruses are known to trigger immune thrombocytopenic purpura (ITP), but the disease is rarely described in association with coronavirus. We describe the case of acute ITP associated with coronavirus disease 19 (COVID-19) in an 86-year-old woman. Intravenous gamma-globulin and corticosteroids were effective on platelet count evolution.
Keywords: COVID-19; Coronavirus; Corticosteroids; Gamma-globulin; Immune; Thrombocytopenic purpura.