tetano
Editor, Senior Moderator
J Med Virol
. 2021 Mar 16.
doi: 10.1002/jmv.26942. Online ahead of print.
An Evaluation of Patients with A Previous Endemic Coronavirus Infection during the COVID-19 Pandemic
Baris Otlu[SUP] 1 [/SUP], Yusuf Yakupogullari[SUP] 1 [/SUP], Elif Seren Tanriverdi[SUP] 1 [/SUP], Yasar Bayindir[SUP] 2 [/SUP]
Affiliations
Abstract
Few studies exist on the clinical manifestation of COVID-19 in patients who previously had a common cold due to an endemic coronavirus (eCoV). In a retrospective scan of the data obtained in our microbiology laboratory, 64 patients who were diagnosed with an eCoV infection between 2016 and 2020 were identified. National COVID-19 surveillance data showed that four (6.2%) of 64 patients were infected with SARS-CoV-2 by the end of 2020 while, simultaneously, the COVID-19 prevalence in the city of Malatya ranged from 7.8% (PCR-based diagnosis) to 9.2% (total diagnosis). The differences were found statistically significant (6.2 vs 7.8%, p<0.01; 6.2 vs 9.2%, p<0.001). Patient interviews and evaluation of medical records revealed that these four patients did not manifest any severe COVID-19 symptoms despite their substantial co-morbidities, and they did not require hospitalization. Consequently, despite a low number of samples, we determined a lower frequency of COVID-19 among the patients who had a prior eCoV infection, and the results of this study support the previous findings that people with a prior eCoV infection develop a milder case of COVID-19. Our results may provide some insights for future studies aiming at vaccine development, but detailed investigations are still required. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus < Virus classification; Pandemics < Epidemiology; Respiratory tract < Pathogenesis; SARS coronavirus < Virus classification.
. 2021 Mar 16.
doi: 10.1002/jmv.26942. Online ahead of print.
An Evaluation of Patients with A Previous Endemic Coronavirus Infection during the COVID-19 Pandemic
Baris Otlu[SUP] 1 [/SUP], Yusuf Yakupogullari[SUP] 1 [/SUP], Elif Seren Tanriverdi[SUP] 1 [/SUP], Yasar Bayindir[SUP] 2 [/SUP]
Affiliations
- PMID: 33724483
- DOI: 10.1002/jmv.26942
Abstract
Few studies exist on the clinical manifestation of COVID-19 in patients who previously had a common cold due to an endemic coronavirus (eCoV). In a retrospective scan of the data obtained in our microbiology laboratory, 64 patients who were diagnosed with an eCoV infection between 2016 and 2020 were identified. National COVID-19 surveillance data showed that four (6.2%) of 64 patients were infected with SARS-CoV-2 by the end of 2020 while, simultaneously, the COVID-19 prevalence in the city of Malatya ranged from 7.8% (PCR-based diagnosis) to 9.2% (total diagnosis). The differences were found statistically significant (6.2 vs 7.8%, p<0.01; 6.2 vs 9.2%, p<0.001). Patient interviews and evaluation of medical records revealed that these four patients did not manifest any severe COVID-19 symptoms despite their substantial co-morbidities, and they did not require hospitalization. Consequently, despite a low number of samples, we determined a lower frequency of COVID-19 among the patients who had a prior eCoV infection, and the results of this study support the previous findings that people with a prior eCoV infection develop a milder case of COVID-19. Our results may provide some insights for future studies aiming at vaccine development, but detailed investigations are still required. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus < Virus classification; Pandemics < Epidemiology; Respiratory tract < Pathogenesis; SARS coronavirus < Virus classification.