tetano
Editor, Senior Moderator
J Med Virol
. 2024 Aug;96(8):e29839.
doi: 10.1002/jmv.29839. Anti-Spike IgG antibodies as correlates of protection against SARS-CoV-2 infection in the pre-Omicron and Omicron era
Lisa Seekircher[SUP] 1 [/SUP], Manfred Astl[SUP] 2 [/SUP], Lena Tschiderer[SUP] 1 [/SUP], Gregor A Wachter[SUP] 2 [/SUP], Julia Penz[SUP] 2 [/SUP], Bernhard Pfeifer[SUP] 3 4 [/SUP], Andreas Huber[SUP] 3 [/SUP], Pedro M Afonso[SUP] 5 6 [/SUP], Manfred Gaber[SUP] 7 [/SUP], Harald Schennach[SUP] 2 [/SUP], Anita Siller[SUP] 2 [/SUP], Peter Willeit[SUP] 1 8 9 [/SUP]
Affiliations
Anti-Spike IgG antibodies against SARS-CoV-2, which are elicited by vaccination and infection, are correlates of protection against infection with pre-Omicron variants. Whether this association can be generalized to infections with Omicron variants is unclear. We conducted a retrospective cohort study with 8457 blood donors in Tyrol, Austria, analyzing 15,340 anti-Spike IgG antibody measurements from March 2021 to December 2022 assessed by Abbott SARS-CoV-2 IgG II chemiluminescent microparticle immunoassay. Using a Bayesian joint model, we estimated antibody trajectories and adjusted hazard ratios for incident SARS-CoV-2 infection ascertained by self-report or seroconversion of anti-Nucleocapsid antibodies. At the time of their earliest available anti-Spike IgG antibody measurement (median November 23, 2021), participants had a median age of 46.0 years (IQR 32.8-55.2), with 45.3% being female, 41.3% having a prior SARS-CoV-2 infection, and 75.5% having received at least one dose of a COVID-19 vaccine. Among 6159 participants with endpoint data, 3700 incident SARS-CoV-2 infections with predominantly Omicron sublineages were recorded over a median of 8.8 months (IQR 5.7-12.4). The age- and sex-adjusted hazard ratio for SARS-CoV-2 associated with having twice the anti-Spike IgG antibody titer was 0.875 (95% credible interval 0.868-0.881) overall, 0.842 (0.827-0.856) during 2021, and 0.884 (0.877-0.891) during 2022 (all p < 0.001). The associations were similar in females and males (P[SUB]interaction[/SUB] = 0.673) and across age (P[SUB]interaction[/SUB] = 0.590). Higher anti-Spike IgG antibody titers were associated with reduced risk of incident SARS-CoV-2 infection across the entire observation period. While the magnitude of association was slightly weakened in the Omicron era, anti-Spike IgG antibody continues to be a suitable correlate of protection against newer SARS-CoV-2 variants.
Keywords: Bayesian joint model; anti‐Spike IgG antibody trajectories; blood donors; correlate of protection against infection; incident SARS‐CoV‐2 infection; pre‐Omicron and Omicron era.
. 2024 Aug;96(8):e29839.
doi: 10.1002/jmv.29839. Anti-Spike IgG antibodies as correlates of protection against SARS-CoV-2 infection in the pre-Omicron and Omicron era
Lisa Seekircher[SUP] 1 [/SUP], Manfred Astl[SUP] 2 [/SUP], Lena Tschiderer[SUP] 1 [/SUP], Gregor A Wachter[SUP] 2 [/SUP], Julia Penz[SUP] 2 [/SUP], Bernhard Pfeifer[SUP] 3 4 [/SUP], Andreas Huber[SUP] 3 [/SUP], Pedro M Afonso[SUP] 5 6 [/SUP], Manfred Gaber[SUP] 7 [/SUP], Harald Schennach[SUP] 2 [/SUP], Anita Siller[SUP] 2 [/SUP], Peter Willeit[SUP] 1 8 9 [/SUP]
Affiliations
- PMID: 39105391
- DOI: 10.1002/jmv.29839
Anti-Spike IgG antibodies against SARS-CoV-2, which are elicited by vaccination and infection, are correlates of protection against infection with pre-Omicron variants. Whether this association can be generalized to infections with Omicron variants is unclear. We conducted a retrospective cohort study with 8457 blood donors in Tyrol, Austria, analyzing 15,340 anti-Spike IgG antibody measurements from March 2021 to December 2022 assessed by Abbott SARS-CoV-2 IgG II chemiluminescent microparticle immunoassay. Using a Bayesian joint model, we estimated antibody trajectories and adjusted hazard ratios for incident SARS-CoV-2 infection ascertained by self-report or seroconversion of anti-Nucleocapsid antibodies. At the time of their earliest available anti-Spike IgG antibody measurement (median November 23, 2021), participants had a median age of 46.0 years (IQR 32.8-55.2), with 45.3% being female, 41.3% having a prior SARS-CoV-2 infection, and 75.5% having received at least one dose of a COVID-19 vaccine. Among 6159 participants with endpoint data, 3700 incident SARS-CoV-2 infections with predominantly Omicron sublineages were recorded over a median of 8.8 months (IQR 5.7-12.4). The age- and sex-adjusted hazard ratio for SARS-CoV-2 associated with having twice the anti-Spike IgG antibody titer was 0.875 (95% credible interval 0.868-0.881) overall, 0.842 (0.827-0.856) during 2021, and 0.884 (0.877-0.891) during 2022 (all p < 0.001). The associations were similar in females and males (P[SUB]interaction[/SUB] = 0.673) and across age (P[SUB]interaction[/SUB] = 0.590). Higher anti-Spike IgG antibody titers were associated with reduced risk of incident SARS-CoV-2 infection across the entire observation period. While the magnitude of association was slightly weakened in the Omicron era, anti-Spike IgG antibody continues to be a suitable correlate of protection against newer SARS-CoV-2 variants.
Keywords: Bayesian joint model; anti‐Spike IgG antibody trajectories; blood donors; correlate of protection against infection; incident SARS‐CoV‐2 infection; pre‐Omicron and Omicron era.