tetano
Editor, Senior Moderator
J Med Virol
. 2021 Nov 5.
doi: 10.1002/jmv.27435. Online ahead of print.
Associations of heart failure with susceptibility and severe complications of COVID-19: A nationwide cohort study
Hyung Jun Kim[SUP] 1 [/SUP], Moo-Suk Park[SUP] 1 [/SUP], Jae Il Shin[SUP] 2 [/SUP], Jin Park[SUP] 1 [/SUP], Dong-Hyeok Kim[SUP] 3 [/SUP], Jimin Jeon[SUP] 4 [/SUP], Jinkwon Kim[SUP] 4 [/SUP], Tae-Jin Song[SUP] 1 [/SUP]
Affiliations
Abstract
Problem: Infection is associated with occurrence and worsening of heart failure (HF). However, studies on the association of susceptibility and severe complications of coronavirus disease 2019 (COVID-19) with HF history are limited.
Method of study: From the Korean nationwide COVID-19 dataset, 212,678 participants with at least one severe acute respiratory syndrome coronavirus 2 real-time reverse transcription polymerase chain reaction (RT PCR) test were included between Jan 1 and June 4, 2020. To investigate the association of HF with susceptibility and severe complications of COVID-19, 1:5 ratio propensity score matching (PSM) and logistic regression analysis were performed. The primary outcome was a composite outcome of mechanical ventilation, intensive care unit admission, and death.
Results: After PSM, COVID-19 PCR positivity did not show a significant difference according to HF history in multivariable analysis (odds ratio (OR): 0.91, 95% confidence interval (CI) (0.79 - 1.04), p = 0.146). Of 7,630 individuals with confirmed COVID-19 infection, 310 (4.1%) had HF history. The overall primary outcome occurred in 426 (5.6%) individuals, including 159 (2.1%) cases of mechanical ventilation, 254 (3.3%) cases of intensive care unit admission, and 215 (2.8%) cases of death. In multivariate logistic analysis, presence of HF history was associated independently with primary outcome (OR: 1.99, 95% CI: 1.42 - 2.79, p < 0.001), particularly mortality (OR: 2.02, 95% CI: 1.36 - 3.00, p < 0.001).
Conclusions: Our study demonstrated that HF history is associated poor prognosis, particularly mortality, in COVID-19. Patients with HF can have severe complication if infected with COVID-19; therefore, careful management are necessary. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Heart failure; Intensive care unit; Mechanical ventilation; Mortality.
. 2021 Nov 5.
doi: 10.1002/jmv.27435. Online ahead of print.
Associations of heart failure with susceptibility and severe complications of COVID-19: A nationwide cohort study
Hyung Jun Kim[SUP] 1 [/SUP], Moo-Suk Park[SUP] 1 [/SUP], Jae Il Shin[SUP] 2 [/SUP], Jin Park[SUP] 1 [/SUP], Dong-Hyeok Kim[SUP] 3 [/SUP], Jimin Jeon[SUP] 4 [/SUP], Jinkwon Kim[SUP] 4 [/SUP], Tae-Jin Song[SUP] 1 [/SUP]
Affiliations
- PMID: 34738248
- DOI: 10.1002/jmv.27435
Abstract
Problem: Infection is associated with occurrence and worsening of heart failure (HF). However, studies on the association of susceptibility and severe complications of coronavirus disease 2019 (COVID-19) with HF history are limited.
Method of study: From the Korean nationwide COVID-19 dataset, 212,678 participants with at least one severe acute respiratory syndrome coronavirus 2 real-time reverse transcription polymerase chain reaction (RT PCR) test were included between Jan 1 and June 4, 2020. To investigate the association of HF with susceptibility and severe complications of COVID-19, 1:5 ratio propensity score matching (PSM) and logistic regression analysis were performed. The primary outcome was a composite outcome of mechanical ventilation, intensive care unit admission, and death.
Results: After PSM, COVID-19 PCR positivity did not show a significant difference according to HF history in multivariable analysis (odds ratio (OR): 0.91, 95% confidence interval (CI) (0.79 - 1.04), p = 0.146). Of 7,630 individuals with confirmed COVID-19 infection, 310 (4.1%) had HF history. The overall primary outcome occurred in 426 (5.6%) individuals, including 159 (2.1%) cases of mechanical ventilation, 254 (3.3%) cases of intensive care unit admission, and 215 (2.8%) cases of death. In multivariate logistic analysis, presence of HF history was associated independently with primary outcome (OR: 1.99, 95% CI: 1.42 - 2.79, p < 0.001), particularly mortality (OR: 2.02, 95% CI: 1.36 - 3.00, p < 0.001).
Conclusions: Our study demonstrated that HF history is associated poor prognosis, particularly mortality, in COVID-19. Patients with HF can have severe complication if infected with COVID-19; therefore, careful management are necessary. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Heart failure; Intensive care unit; Mechanical ventilation; Mortality.