tetano
Editor, Senior Moderator
J Med Virol
. 2022 Apr 26.
doi: 10.1002/jmv.27816. Online ahead of print.
Coinfection of leptospirosis and Coronavirus disease 2019: a retrospective case series from a coastal region in South India
Nitin Gupta[SUP] 1 2 [/SUP], William Wilson[SUP] 3 [/SUP], Prithvishree Ravindra[SUP] 3 [/SUP], Roshini Raghu[SUP] 3 [/SUP], Kavitha Saravu[SUP] 1 2 [/SUP]
Affiliations
Abstract
Introduction: During the monsoon season of 2020, the coastal areas of South India were endemic to both Leptospirosis and COVID-19. This study aimed to investigate the clinical features and outcomes of patients infected with both infections.
Methodology: A retrospective review of charts of all patients with COVID-19 who were also diagnosed with leptospirosis by IgM ELISA was undertaken. The clinical features, laboratory report, treatment details and outcomes of all the included patients were recorded. The collected data were summarised as the frequency with percentage for categorical data and the mean or median for continuous data.
Results: Twenty four cases of coinfections were admitted between July and November 2020. Most of these patients were categorised as severe COVID-19 (n=15, 62.5%). Acute Kidney Injury was seen in 79.2% (n=19) patients, while raised bilirubin was present in 79.2% (n=19) of the patients. All patients had raised CRP, while all but one had raised procalcitonin. Thrombocytopenia, leucocytosis and leukocytopenia were seen in 91.7% (n=22), 45.8% (n=11) and 12.5% (n=3) of the patients. The median duration of hospital stay was 11 (8.25-15) days. A total of 79.2% (n=19) of the patients improved and were discharged, while 20.8% (n=5) died during the hospital stay.
Conclusion: Patients with fever and atypical manifestations such as hepatic dysfunction, renal dysfunction, and thrombocytopenia should be evaluated for leptospirosis even if they are COVID positive. This article is protected by copyright. All rights reserved.
Keywords: Acute febrile illness; COVID-19; Leptospira; Weil's disease.
. 2022 Apr 26.
doi: 10.1002/jmv.27816. Online ahead of print.
Coinfection of leptospirosis and Coronavirus disease 2019: a retrospective case series from a coastal region in South India
Nitin Gupta[SUP] 1 2 [/SUP], William Wilson[SUP] 3 [/SUP], Prithvishree Ravindra[SUP] 3 [/SUP], Roshini Raghu[SUP] 3 [/SUP], Kavitha Saravu[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35474463
- DOI: 10.1002/jmv.27816
Abstract
Introduction: During the monsoon season of 2020, the coastal areas of South India were endemic to both Leptospirosis and COVID-19. This study aimed to investigate the clinical features and outcomes of patients infected with both infections.
Methodology: A retrospective review of charts of all patients with COVID-19 who were also diagnosed with leptospirosis by IgM ELISA was undertaken. The clinical features, laboratory report, treatment details and outcomes of all the included patients were recorded. The collected data were summarised as the frequency with percentage for categorical data and the mean or median for continuous data.
Results: Twenty four cases of coinfections were admitted between July and November 2020. Most of these patients were categorised as severe COVID-19 (n=15, 62.5%). Acute Kidney Injury was seen in 79.2% (n=19) patients, while raised bilirubin was present in 79.2% (n=19) of the patients. All patients had raised CRP, while all but one had raised procalcitonin. Thrombocytopenia, leucocytosis and leukocytopenia were seen in 91.7% (n=22), 45.8% (n=11) and 12.5% (n=3) of the patients. The median duration of hospital stay was 11 (8.25-15) days. A total of 79.2% (n=19) of the patients improved and were discharged, while 20.8% (n=5) died during the hospital stay.
Conclusion: Patients with fever and atypical manifestations such as hepatic dysfunction, renal dysfunction, and thrombocytopenia should be evaluated for leptospirosis even if they are COVID positive. This article is protected by copyright. All rights reserved.
Keywords: Acute febrile illness; COVID-19; Leptospira; Weil's disease.