tetano
Editor, Senior Moderator
J Med Virol
. 2021 Sep 7.
doi: 10.1002/jmv.27319. Online ahead of print.
Comparison of demographic and clinical characteristics of hospitalized COVID-19 patients with severe/critical illness in the first wave vs the second wave
Elif Sargin Altunok[SUP] 1 [/SUP], Celal Satici[SUP] 2 [/SUP], Veysel Dinc[SUP] 3 [/SUP], Sadettin Kamat[SUP] 4 [/SUP], Mustafa Alkan[SUP] 1 [/SUP], Mustafa Asim Demirkol[SUP] 4 [/SUP], Ilkim Deniz Toprak[SUP] 5 [/SUP], Muhammed Emin Kostek[SUP] 5 [/SUP], Semih Yazla[SUP] 6 [/SUP], Sinem Nihal Esatoglu[SUP] 7 [/SUP]
Affiliations
Abstract
Background: Due to current advances and growing experience in the management of coronavirus Disease 2019 (COVID-19), the outcome of COVID-19 patients with severe/critical illness would be expected to be better in the second wave compared to the first wave. Since our hospitalization criteria has been change in the second wave, we aimed to investigate whether a favorable outcome occurred in hospitalized COVID-19 patients with only severe/critical illness.
Methods: Among 642 laboratory confirmed hospitalized COVID-19 patients in the first wave and 1121 in the second wave, those who met World Health Organization (WHO) definitions for severe or critical illness on admission or during follow-up were surveyed. Data on demographics, comorbidities, C-reactive protein levels on admission, and outcomes were obtained from electronic hospital database. Univariate analysis was performed to compare the characteristics of patients in the first and second waves.
Results: There were 228 (35.5%) patients with severe/critical illness in the first wave and 681 (60.7%) in the second wave. Both groups were similar in terms of age, gender, and comorbidities other than chronic kidney disease. Median serum CRP levels were significantly higher in patients in the second wave compared to those in the first wave (109 mg/L (IQR: 65-157) vs 87 mg/L (IQR: 39-140); p<0.001). However, ICU admission and mortality rates were similar among the waves.
Conclusions: Even though a lower mortality rate in the second wave has been reported in previous studies including all hospitalized COVID-19 patients, we found similar demographics and outcomes among hospitalized COVID-19 patients with severe/critical illness in the first and second wave. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Turkey; demographic characteristics; mortality; the first vs second wave.
. 2021 Sep 7.
doi: 10.1002/jmv.27319. Online ahead of print.
Comparison of demographic and clinical characteristics of hospitalized COVID-19 patients with severe/critical illness in the first wave vs the second wave
Elif Sargin Altunok[SUP] 1 [/SUP], Celal Satici[SUP] 2 [/SUP], Veysel Dinc[SUP] 3 [/SUP], Sadettin Kamat[SUP] 4 [/SUP], Mustafa Alkan[SUP] 1 [/SUP], Mustafa Asim Demirkol[SUP] 4 [/SUP], Ilkim Deniz Toprak[SUP] 5 [/SUP], Muhammed Emin Kostek[SUP] 5 [/SUP], Semih Yazla[SUP] 6 [/SUP], Sinem Nihal Esatoglu[SUP] 7 [/SUP]
Affiliations
- PMID: 34491575
- DOI: 10.1002/jmv.27319
Abstract
Background: Due to current advances and growing experience in the management of coronavirus Disease 2019 (COVID-19), the outcome of COVID-19 patients with severe/critical illness would be expected to be better in the second wave compared to the first wave. Since our hospitalization criteria has been change in the second wave, we aimed to investigate whether a favorable outcome occurred in hospitalized COVID-19 patients with only severe/critical illness.
Methods: Among 642 laboratory confirmed hospitalized COVID-19 patients in the first wave and 1121 in the second wave, those who met World Health Organization (WHO) definitions for severe or critical illness on admission or during follow-up were surveyed. Data on demographics, comorbidities, C-reactive protein levels on admission, and outcomes were obtained from electronic hospital database. Univariate analysis was performed to compare the characteristics of patients in the first and second waves.
Results: There were 228 (35.5%) patients with severe/critical illness in the first wave and 681 (60.7%) in the second wave. Both groups were similar in terms of age, gender, and comorbidities other than chronic kidney disease. Median serum CRP levels were significantly higher in patients in the second wave compared to those in the first wave (109 mg/L (IQR: 65-157) vs 87 mg/L (IQR: 39-140); p<0.001). However, ICU admission and mortality rates were similar among the waves.
Conclusions: Even though a lower mortality rate in the second wave has been reported in previous studies including all hospitalized COVID-19 patients, we found similar demographics and outcomes among hospitalized COVID-19 patients with severe/critical illness in the first and second wave. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Turkey; demographic characteristics; mortality; the first vs second wave.