tetano
Editor, Senior Moderator
J Med Virol
. 2023 Sep;95(9):e29094.
doi: 10.1002/jmv.29094. Comparison of semen parameters in the same patients before and after diagnosis of COVID-19
Cihan Cakir[SUP] 1 [/SUP], Goktan Kuspinar[SUP] 1 [/SUP], Gizem Kurt[SUP] 1 [/SUP], Miray Berber[SUP] 1 [/SUP], Kiper Aslan[SUP] 2 [/SUP], Isil Kasapoglu[SUP] 2 [/SUP], Gurkan Uncu[SUP] 2 [/SUP], Berrin Avcı[SUP] 1 [/SUP]
Affiliations
Clinical and histopathological evidence suggest that the male reproductive system may be negatively impacted in patients with coronavirus disease (COVID-19). The objective of this study is to investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on semen parameters by comparing semen analyses before and after COVID-19 diagnosis in the same patient. We retrospectively analyzed 342 semen analyses by reviewing medical records. The study included two groups of patients: (i) those who underwent two consecutive semen analyses within 6 months, one before (n = 114) and one after (n = 114) COVID-19 diagnosis, and (ii) a control group (n = 114) that was age-matched and did not receive a diagnosis of COVID-19. The study results indicated a significant decrease in semen volume, total sperm count per ejaculate, progressive motile sperm count, total motile sperm count, and normal sperm morphology after SARS-CoV-2 infection in comparison to their respective values before the infection. Subgroup analyses showed that the duration of COVID-19 diagnosis (short-term vs. long-term) did not impact the changes in semen parameters. However, fever during the COVID-19 process had a negative effect on semen parameters, particularly sperm concentration, unlike in patients without fever. In conclusion, our findings suggest that SARS-CoV-2 infection is associated with a decline in semen quality, which may potentially impact male fertility. Furthermore, it's important to note that the negative effects on semen parameters may persist in the long-term. Our results also indicate that fever during active infection could be a significant risk factor that negatively affects spermatogenesis.
Keywords: COVID-19; SARS-CoV-2; male infertility; semen parameters; spermatogenesis.
. 2023 Sep;95(9):e29094.
doi: 10.1002/jmv.29094. Comparison of semen parameters in the same patients before and after diagnosis of COVID-19
Cihan Cakir[SUP] 1 [/SUP], Goktan Kuspinar[SUP] 1 [/SUP], Gizem Kurt[SUP] 1 [/SUP], Miray Berber[SUP] 1 [/SUP], Kiper Aslan[SUP] 2 [/SUP], Isil Kasapoglu[SUP] 2 [/SUP], Gurkan Uncu[SUP] 2 [/SUP], Berrin Avcı[SUP] 1 [/SUP]
Affiliations
- PMID: 37695129
- DOI: 10.1002/jmv.29094
Clinical and histopathological evidence suggest that the male reproductive system may be negatively impacted in patients with coronavirus disease (COVID-19). The objective of this study is to investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on semen parameters by comparing semen analyses before and after COVID-19 diagnosis in the same patient. We retrospectively analyzed 342 semen analyses by reviewing medical records. The study included two groups of patients: (i) those who underwent two consecutive semen analyses within 6 months, one before (n = 114) and one after (n = 114) COVID-19 diagnosis, and (ii) a control group (n = 114) that was age-matched and did not receive a diagnosis of COVID-19. The study results indicated a significant decrease in semen volume, total sperm count per ejaculate, progressive motile sperm count, total motile sperm count, and normal sperm morphology after SARS-CoV-2 infection in comparison to their respective values before the infection. Subgroup analyses showed that the duration of COVID-19 diagnosis (short-term vs. long-term) did not impact the changes in semen parameters. However, fever during the COVID-19 process had a negative effect on semen parameters, particularly sperm concentration, unlike in patients without fever. In conclusion, our findings suggest that SARS-CoV-2 infection is associated with a decline in semen quality, which may potentially impact male fertility. Furthermore, it's important to note that the negative effects on semen parameters may persist in the long-term. Our results also indicate that fever during active infection could be a significant risk factor that negatively affects spermatogenesis.
Keywords: COVID-19; SARS-CoV-2; male infertility; semen parameters; spermatogenesis.