tetano
Editor, Senior Moderator
J Med Virol
. 2020 Dec 10.
doi: 10.1002/jmv.26724. Online ahead of print.
Diagnosis options in patients suffering from COVID-19- like symptoms
Chlo? Dimeglio[SUP] 1 2 [/SUP], Samia Collot[SUP] 3 [/SUP], Florence Abravanel[SUP] 1 2 [/SUP], Karine Saun?[SUP] 1 2 [/SUP], S?bastien Lhomme[SUP] 1 2 [/SUP], Marie Faruch[SUP] 4 [/SUP], Nicolas Sans[SUP] 4 [/SUP], Jacques Izopet[SUP] 1 2 [/SUP]
Affiliations
Abstract
The role and performance of chest CT in the diagnosis of the coronavirus disease 2019 pandemic remains under active investigation. A recent case report in this journal found that a COVID-19 diagnosis has been made from the serological results despite first CT scan and RT-PCR negative results. We have included 311 consecutive patients with COVID-19-like symptoms who underwent a RT-PCR test on nasopharyngeal swab samples and a chest CT scan. Patients with a positive chest scan and a negative RT-PCR were screened for serum total anti-SARS-CoV-2 antibodies 2 months after the onset of symptoms using the Wantai test in order to arbitrate between RT-PCR and CT scans discordant results. Most of the RT-PCR and chest CT results agreed but the serological tests indicate that most CT positive/NAT negative patients are not infected by SARS-CoV-2 and alternative diagnoses should be seriously considered. This article is protected by copyright. All rights reserved.
Keywords: Pandemics < Epidemiology; Respiratory tract < Pathogenesis; SARS coronavirus < Virus classification.
. 2020 Dec 10.
doi: 10.1002/jmv.26724. Online ahead of print.
Diagnosis options in patients suffering from COVID-19- like symptoms
Chlo? Dimeglio[SUP] 1 2 [/SUP], Samia Collot[SUP] 3 [/SUP], Florence Abravanel[SUP] 1 2 [/SUP], Karine Saun?[SUP] 1 2 [/SUP], S?bastien Lhomme[SUP] 1 2 [/SUP], Marie Faruch[SUP] 4 [/SUP], Nicolas Sans[SUP] 4 [/SUP], Jacques Izopet[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33300117
- DOI: 10.1002/jmv.26724
Abstract
The role and performance of chest CT in the diagnosis of the coronavirus disease 2019 pandemic remains under active investigation. A recent case report in this journal found that a COVID-19 diagnosis has been made from the serological results despite first CT scan and RT-PCR negative results. We have included 311 consecutive patients with COVID-19-like symptoms who underwent a RT-PCR test on nasopharyngeal swab samples and a chest CT scan. Patients with a positive chest scan and a negative RT-PCR were screened for serum total anti-SARS-CoV-2 antibodies 2 months after the onset of symptoms using the Wantai test in order to arbitrate between RT-PCR and CT scans discordant results. Most of the RT-PCR and chest CT results agreed but the serological tests indicate that most CT positive/NAT negative patients are not infected by SARS-CoV-2 and alternative diagnoses should be seriously considered. This article is protected by copyright. All rights reserved.
Keywords: Pandemics < Epidemiology; Respiratory tract < Pathogenesis; SARS coronavirus < Virus classification.