tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jul 13.
doi: 10.1002/jmv.27998. Online ahead of print.
Dynamics of nasopharyngeal tract phageome and association with disease severity and age of patients during three waves of COVID-19
Carlo Ferravante[SUP] 1 [/SUP], Berin S Arslan-Gatz[SUP] 2 [/SUP], Federica Dell'Annunziata[SUP] 2 [/SUP], Domenico Palumbo[SUP] 1 [/SUP], Jessica Lamberti[SUP] 1 [/SUP], Elena Alexandrova[SUP] 1 [/SUP], Domenico Di Rosa[SUP] 1 [/SUP], Oriana Strianese[SUP] 3 [/SUP], Alessandro Giordano[SUP] 1 [/SUP], Luigi Palo[SUP] 1 [/SUP], Giorgio Giurato[SUP] 1 3 [/SUP], Francesco A Salzano[SUP] 4 [/SUP], Massimiliano Galdiero[SUP] 2 [/SUP], Alessandro Weisz[SUP] 1 3 5 [/SUP], Gianluigi Franci[SUP] 4 [/SUP], Francesca Rizzo[SUP] 1 3 [/SUP], Veronica Folliero[SUP] 2 [/SUP]
Affiliations
Abstract
In December 2019, several patients were hospitalized and diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which subsequently led to a global pandemic. To date, there are no studies evaluating the relationship between the respiratory phageome and the SARS-CoV-2 infection. The current study investigated the phageome profiles in the nasopharyngeal swabs collected from 55 patients during the three different waves of COVID-19 in the Campania Region (Southern Italy). Data obtained from the taxonomic profiling show that phage families belonging to the order Caudovirales have a high abundance in the patient samples. Moreover, the severity of the COVID-19 infection seems to be correlated with the phage abundance. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; bacteriophages; phageome; taxonomic analysis.
. 2022 Jul 13.
doi: 10.1002/jmv.27998. Online ahead of print.
Dynamics of nasopharyngeal tract phageome and association with disease severity and age of patients during three waves of COVID-19
Carlo Ferravante[SUP] 1 [/SUP], Berin S Arslan-Gatz[SUP] 2 [/SUP], Federica Dell'Annunziata[SUP] 2 [/SUP], Domenico Palumbo[SUP] 1 [/SUP], Jessica Lamberti[SUP] 1 [/SUP], Elena Alexandrova[SUP] 1 [/SUP], Domenico Di Rosa[SUP] 1 [/SUP], Oriana Strianese[SUP] 3 [/SUP], Alessandro Giordano[SUP] 1 [/SUP], Luigi Palo[SUP] 1 [/SUP], Giorgio Giurato[SUP] 1 3 [/SUP], Francesco A Salzano[SUP] 4 [/SUP], Massimiliano Galdiero[SUP] 2 [/SUP], Alessandro Weisz[SUP] 1 3 5 [/SUP], Gianluigi Franci[SUP] 4 [/SUP], Francesca Rizzo[SUP] 1 3 [/SUP], Veronica Folliero[SUP] 2 [/SUP]
Affiliations
- PMID: 35831579
- DOI: 10.1002/jmv.27998
Abstract
In December 2019, several patients were hospitalized and diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which subsequently led to a global pandemic. To date, there are no studies evaluating the relationship between the respiratory phageome and the SARS-CoV-2 infection. The current study investigated the phageome profiles in the nasopharyngeal swabs collected from 55 patients during the three different waves of COVID-19 in the Campania Region (Southern Italy). Data obtained from the taxonomic profiling show that phage families belonging to the order Caudovirales have a high abundance in the patient samples. Moreover, the severity of the COVID-19 infection seems to be correlated with the phage abundance. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; bacteriophages; phageome; taxonomic analysis.