tetano
Editor, Senior Moderator
J Med Virol
. 2023 Dec;95(12):e29272.
doi: 10.1002/jmv.29272. Eliminating COVID-19 as the immediate culprit for igniting pancreatitis
Peng Ge[SUP] 1 2 3 [/SUP], Yalan Luo[SUP] 1 2 3 [/SUP], Jie Liu[SUP] 1 2 3 [/SUP], Jin Liu[SUP] 1 3 [/SUP], Haiyun Wen[SUP] 1 2 3 [/SUP], Guixin Zhang[SUP] 1 2 3 [/SUP], Hailong Chen[SUP] 1 2 3 [/SUP]
Affiliations
The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID-19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID-19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID-19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID-19 and CP. A direct causal relationship between genetically predicted COVID-19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID-19 as a definitive cause of pancreatitis.
Keywords: COVID-19; Mendelian randomization; genetic variation; pancreatitis; risk.
. 2023 Dec;95(12):e29272.
doi: 10.1002/jmv.29272. Eliminating COVID-19 as the immediate culprit for igniting pancreatitis
Peng Ge[SUP] 1 2 3 [/SUP], Yalan Luo[SUP] 1 2 3 [/SUP], Jie Liu[SUP] 1 2 3 [/SUP], Jin Liu[SUP] 1 3 [/SUP], Haiyun Wen[SUP] 1 2 3 [/SUP], Guixin Zhang[SUP] 1 2 3 [/SUP], Hailong Chen[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 38054501
- DOI: 10.1002/jmv.29272
The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID-19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID-19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID-19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID-19 and CP. A direct causal relationship between genetically predicted COVID-19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID-19 as a definitive cause of pancreatitis.
Keywords: COVID-19; Mendelian randomization; genetic variation; pancreatitis; risk.