tetano
Editor, Senior Moderator
J Med Virol
. 2022 Sep 22.
doi: 10.1002/jmv.28167. Online ahead of print.
Emergence of S gene-based quasispecies explains an optimal adaptation of Omicron BA.5 subvariant in the immunocompetent vaccinated human host
Serena Messali 1 , Antonella Bugatti 1 , Federica Filippini 1 , Arnaldo Caruso 1 , Francesca Caccuri 1
Affiliations
PMID: 36147029 DOI: 10.1002/jmv.28167
Abstract
In this study, we collected two subsequent swabs from 7 immunocompetent up to date vaccinated healthcare workers undergoing mild symptomatic SARS-CoV-2 infection, and applied a next generation sequencing approach to establish the intra-host dynamics of SARS-CoV-2 quasispecies. Data obtained show that complex dynamics of viral quasispecies occur over a short period of time in patients infected with BA.1 and BA.2. as compared to patients infected with BA.2.3 and BA.5. The low frequency of quasispecies in BA.2.3- and BA.5-infected patients supports the hypothesis that these omicron sub-lineages are adapted to vaccine-elicited immune responses. This article is protected by copyright. All rights reserved.
Keywords: Evolution; Mutation/Mutation; SARS coronavirus; Virus classification; rate.
. 2022 Sep 22.
doi: 10.1002/jmv.28167. Online ahead of print.
Emergence of S gene-based quasispecies explains an optimal adaptation of Omicron BA.5 subvariant in the immunocompetent vaccinated human host
Serena Messali 1 , Antonella Bugatti 1 , Federica Filippini 1 , Arnaldo Caruso 1 , Francesca Caccuri 1
Affiliations
PMID: 36147029 DOI: 10.1002/jmv.28167
Abstract
In this study, we collected two subsequent swabs from 7 immunocompetent up to date vaccinated healthcare workers undergoing mild symptomatic SARS-CoV-2 infection, and applied a next generation sequencing approach to establish the intra-host dynamics of SARS-CoV-2 quasispecies. Data obtained show that complex dynamics of viral quasispecies occur over a short period of time in patients infected with BA.1 and BA.2. as compared to patients infected with BA.2.3 and BA.5. The low frequency of quasispecies in BA.2.3- and BA.5-infected patients supports the hypothesis that these omicron sub-lineages are adapted to vaccine-elicited immune responses. This article is protected by copyright. All rights reserved.
Keywords: Evolution; Mutation/Mutation; SARS coronavirus; Virus classification; rate.