tetano
Editor, Senior Moderator
J Med Virol
. 2021 Mar 31.
doi: 10.1002/jmv.26983. Online ahead of print.
Evaluation of rapid antigen tests based on saliva for the detection of SARS-CoV-2
Tamara Seitz[SUP] 1 [/SUP], Stefanie Schindler[SUP] 2 [/SUP], Patrick Winkelmeyer[SUP] 2 [/SUP], Bernhard Zach[SUP] 2 [/SUP], Christoph Wenisch[SUP] 1 [/SUP], Alexander Zoufaly[SUP] 1 [/SUP], Franz Allerberger[SUP] 2 [/SUP]
Affiliations
Abstract
Rapid identification and isolation of with SARS-CoV-2 infected individuals is crucial. Recent studies have shown that RT-PCR from self-collected saliva is a suitable alternative to nasopharyngeal swab. A disadvantage of RT-PCR resulting in a long time until result which may be problematic. To address this problem, in this study a rapid antigen testCE-certified for the detection of SARS-CoV-2 using saliva (COVID-19 Antigen Test Cassette (hypersensitive colloidal gold) was evaluated. An overall sensitivity of saliva rapid antigen test of 44.4% and a specificity of 100% compared with RT-PCR-results from gargle solution as gold standard was shown. The data suggests that rapid antigen tests based on saliva for the detection of SARS-CoV-2 are not a no reliable substitute for RT-PCR. This article is protected by copyright. All rights reserved.
Keywords: Antigen presentation; Epidemiology; Immune responses; Pandemics; SARS coronavirus; Virus classification.
. 2021 Mar 31.
doi: 10.1002/jmv.26983. Online ahead of print.
Evaluation of rapid antigen tests based on saliva for the detection of SARS-CoV-2
Tamara Seitz[SUP] 1 [/SUP], Stefanie Schindler[SUP] 2 [/SUP], Patrick Winkelmeyer[SUP] 2 [/SUP], Bernhard Zach[SUP] 2 [/SUP], Christoph Wenisch[SUP] 1 [/SUP], Alexander Zoufaly[SUP] 1 [/SUP], Franz Allerberger[SUP] 2 [/SUP]
Affiliations
- PMID: 33788280
- DOI: 10.1002/jmv.26983
Abstract
Rapid identification and isolation of with SARS-CoV-2 infected individuals is crucial. Recent studies have shown that RT-PCR from self-collected saliva is a suitable alternative to nasopharyngeal swab. A disadvantage of RT-PCR resulting in a long time until result which may be problematic. To address this problem, in this study a rapid antigen testCE-certified for the detection of SARS-CoV-2 using saliva (COVID-19 Antigen Test Cassette (hypersensitive colloidal gold) was evaluated. An overall sensitivity of saliva rapid antigen test of 44.4% and a specificity of 100% compared with RT-PCR-results from gargle solution as gold standard was shown. The data suggests that rapid antigen tests based on saliva for the detection of SARS-CoV-2 are not a no reliable substitute for RT-PCR. This article is protected by copyright. All rights reserved.
Keywords: Antigen presentation; Epidemiology; Immune responses; Pandemics; SARS coronavirus; Virus classification.