tetano
Editor, Senior Moderator
J Med Virol
. 2024 Mar;96(3):e29543.
doi: 10.1002/jmv.29543. Evaluation of the effectiveness and safety of sequential vaccination with inactivated SARS-CoV-2 vaccine and Ad5-nCoV booster in pediatric liver transplant recipients
Zhigang Zheng[SUP] 1 [/SUP], Huimin Wu[SUP] 1 [/SUP], Xiaowei Sun[SUP] 2 [/SUP], Yefeng Lu[SUP] 1 [/SUP], Yanyan Song[SUP] 3 [/SUP], Yi Luo[SUP] 1 [/SUP], Tao Zhou[SUP] 1 [/SUP], Mingxuan Feng[SUP] 1 [/SUP], Ping Wan[SUP] 1 [/SUP], Jianjun Zhu[SUP] 1 [/SUP], Nan Shen[SUP] 4 [/SUP], Qing Cao[SUP] 5 [/SUP], Ji Liang[SUP] 5 6 [/SUP], Qiang Xia[SUP] 1 7 8 [/SUP], Feng Xue[SUP] 1 [/SUP]
Affiliations
Amidst the COVID-19 pandemic, uncertainty persists among caregivers regarding the vaccination of pediatric liver transplant recipients (PLTRs). This study evaluates the immunogenicity and safety of COVID-19 vaccination in this vulnerable population. A cohort of 30 PLTRs underwent sequential vaccinations with an inactivated SARS-CoV-2 vaccine followed by an Ad5-nCoV booster. We collected and analyzed blood samples pre-vaccination and four weeks post-vaccination to quantify antibody and IGRA (IFN-γ Release Assay) levels. We also documented any adverse reactions occurring within seven days post-vaccination and monitored participants for infections over six months post-vaccination, culminating in a comprehensive statistical analysis. The Ad5-nCoV booster substantially elevated IgG (T1: 18.01, 20%; T2: 66.61, 55%) and nAb (T1: 119.29, 8%; T2: 3799.75, 80%) levels, as well as T-cell responses, in comparison to the initial dose. The first dose was associated with some common adverse reactions, such as injection site pain (13.3%) and fever (16.6%), but a low rate of systemic reactions (16.0%). There was no significant difference in Omicron infection rates or RTPCR conversion times between vaccinated and unvaccinated groups. Notably, following Omicron infection, vaccinated individuals exhibited significantly higher SARS-CoV-2 IgG and nAb titers (average IgG: 231.21 vs. 62.09 S/CO, p = 0.0003; nAb: 5246.11 vs. 2592.07 IU/mL, p = 0.0002). The use of inactivated vaccines followed by an Ad5-nCoV booster in PLTRs is generally safe and elicits a robust humoral response, albeit with limited T-cell responses.
Keywords: Ad5‐nCoV; Omicron; nebulized inhalation vaccine; pediatric liver transplantation.
. 2024 Mar;96(3):e29543.
doi: 10.1002/jmv.29543. Evaluation of the effectiveness and safety of sequential vaccination with inactivated SARS-CoV-2 vaccine and Ad5-nCoV booster in pediatric liver transplant recipients
Zhigang Zheng[SUP] 1 [/SUP], Huimin Wu[SUP] 1 [/SUP], Xiaowei Sun[SUP] 2 [/SUP], Yefeng Lu[SUP] 1 [/SUP], Yanyan Song[SUP] 3 [/SUP], Yi Luo[SUP] 1 [/SUP], Tao Zhou[SUP] 1 [/SUP], Mingxuan Feng[SUP] 1 [/SUP], Ping Wan[SUP] 1 [/SUP], Jianjun Zhu[SUP] 1 [/SUP], Nan Shen[SUP] 4 [/SUP], Qing Cao[SUP] 5 [/SUP], Ji Liang[SUP] 5 6 [/SUP], Qiang Xia[SUP] 1 7 8 [/SUP], Feng Xue[SUP] 1 [/SUP]
Affiliations
- PMID: 38528839
- DOI: 10.1002/jmv.29543
Amidst the COVID-19 pandemic, uncertainty persists among caregivers regarding the vaccination of pediatric liver transplant recipients (PLTRs). This study evaluates the immunogenicity and safety of COVID-19 vaccination in this vulnerable population. A cohort of 30 PLTRs underwent sequential vaccinations with an inactivated SARS-CoV-2 vaccine followed by an Ad5-nCoV booster. We collected and analyzed blood samples pre-vaccination and four weeks post-vaccination to quantify antibody and IGRA (IFN-γ Release Assay) levels. We also documented any adverse reactions occurring within seven days post-vaccination and monitored participants for infections over six months post-vaccination, culminating in a comprehensive statistical analysis. The Ad5-nCoV booster substantially elevated IgG (T1: 18.01, 20%; T2: 66.61, 55%) and nAb (T1: 119.29, 8%; T2: 3799.75, 80%) levels, as well as T-cell responses, in comparison to the initial dose. The first dose was associated with some common adverse reactions, such as injection site pain (13.3%) and fever (16.6%), but a low rate of systemic reactions (16.0%). There was no significant difference in Omicron infection rates or RTPCR conversion times between vaccinated and unvaccinated groups. Notably, following Omicron infection, vaccinated individuals exhibited significantly higher SARS-CoV-2 IgG and nAb titers (average IgG: 231.21 vs. 62.09 S/CO, p = 0.0003; nAb: 5246.11 vs. 2592.07 IU/mL, p = 0.0002). The use of inactivated vaccines followed by an Ad5-nCoV booster in PLTRs is generally safe and elicits a robust humoral response, albeit with limited T-cell responses.
Keywords: Ad5‐nCoV; Omicron; nebulized inhalation vaccine; pediatric liver transplantation.