tetano
Editor, Senior Moderator
J Med Virol
. 2023 Nov;95(11):e29247.
doi: 10.1002/jmv.29247. High sera levels of SARS-CoV-2 N antigen are associated with death in hospitalized COVID-19 patients
Houssem Redha Chenane[SUP] 1 [/SUP], Guillaume Lingas[SUP] 1 [/SUP], Reyene Menidjel[SUP] 1 [/SUP], Cédric Laouenan[SUP] 1 2 [/SUP], Sarah Tubiana[SUP] 1 2 [/SUP], Diane Descamps[SUP] 1 3 [/SUP], Quentin Le Hingrat[SUP] 1 3 [/SUP], Laurent Abel[SUP] 4 5 6 [/SUP], Jérémie Guedj[SUP] 1 [/SUP], Surbhi Malhotra[SUP] 7 [/SUP], Samir Kumar-Singh[SUP] 7 8 [/SUP], Benoit Visseaux[SUP] 1 [/SUP], Jade Ghosn[SUP] 1 9 [/SUP], Charlotte Charpentier[SUP] 1 3 [/SUP], Samuel Lebourgeois[SUP] 1 [/SUP]; French COVID Cohort Study Group
Affiliations
The presence of free severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid-antigen in sera (N-antigenemia) has been shown in COVID-19 patients. However, the link between the quantitative levels of N-antigenemia and COVID-19 disease severity is not entirely understood. To assess the dynamics and clinical association of N-antigen sera levels with disease severity in COVID-19 patients, we analyzed data from patients included in the French COVID cohort, with at least one sera sample between January and September 2020. We assessed N-antigenemia levels and anti-N IgG titers, and patient outcomes was classified in two groups, survival or death. In samples collected within 8 days since symptom onset, we observed that deceased patients had a higher positivity rate (93% vs. 81%; p < 0.001) and higher median levels of predicted N-antigenemia (2500 vs. 1200 pg/mL; p < 0.001) than surviving patients. Predicted time to N-antigen clearance in sera was prolonged in deceased patients compared to survivors (23.3 vs 19.3 days; p < 0.0001). In a subset of patients with both sera and nasopharyngeal (NP) swabs, predicted time to N-antigen clearance in sera was prolonged in deceased patients (p < 0.001), whereas NP viral load clearance did not differ between the groups (p = 0.07). Our results demonstrate a strong relationship between N-antigenemia levels and COVID-19 severity on a prospective cohort.
Keywords: COVID-19; antigenemia; hospitalized; serological marker; severity.
. 2023 Nov;95(11):e29247.
doi: 10.1002/jmv.29247. High sera levels of SARS-CoV-2 N antigen are associated with death in hospitalized COVID-19 patients
Houssem Redha Chenane[SUP] 1 [/SUP], Guillaume Lingas[SUP] 1 [/SUP], Reyene Menidjel[SUP] 1 [/SUP], Cédric Laouenan[SUP] 1 2 [/SUP], Sarah Tubiana[SUP] 1 2 [/SUP], Diane Descamps[SUP] 1 3 [/SUP], Quentin Le Hingrat[SUP] 1 3 [/SUP], Laurent Abel[SUP] 4 5 6 [/SUP], Jérémie Guedj[SUP] 1 [/SUP], Surbhi Malhotra[SUP] 7 [/SUP], Samir Kumar-Singh[SUP] 7 8 [/SUP], Benoit Visseaux[SUP] 1 [/SUP], Jade Ghosn[SUP] 1 9 [/SUP], Charlotte Charpentier[SUP] 1 3 [/SUP], Samuel Lebourgeois[SUP] 1 [/SUP]; French COVID Cohort Study Group
Affiliations
- PMID: 38009713
- DOI: 10.1002/jmv.29247
The presence of free severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid-antigen in sera (N-antigenemia) has been shown in COVID-19 patients. However, the link between the quantitative levels of N-antigenemia and COVID-19 disease severity is not entirely understood. To assess the dynamics and clinical association of N-antigen sera levels with disease severity in COVID-19 patients, we analyzed data from patients included in the French COVID cohort, with at least one sera sample between January and September 2020. We assessed N-antigenemia levels and anti-N IgG titers, and patient outcomes was classified in two groups, survival or death. In samples collected within 8 days since symptom onset, we observed that deceased patients had a higher positivity rate (93% vs. 81%; p < 0.001) and higher median levels of predicted N-antigenemia (2500 vs. 1200 pg/mL; p < 0.001) than surviving patients. Predicted time to N-antigen clearance in sera was prolonged in deceased patients compared to survivors (23.3 vs 19.3 days; p < 0.0001). In a subset of patients with both sera and nasopharyngeal (NP) swabs, predicted time to N-antigen clearance in sera was prolonged in deceased patients (p < 0.001), whereas NP viral load clearance did not differ between the groups (p = 0.07). Our results demonstrate a strong relationship between N-antigenemia levels and COVID-19 severity on a prospective cohort.
Keywords: COVID-19; antigenemia; hospitalized; serological marker; severity.