tetano
Editor, Senior Moderator
J Med Virol
. 2020 Sep 8.
doi: 10.1002/jmv.26493. Online ahead of print.
Immune response against SARS-CoV-2 in pediatric patients including young infants
Yoshiki Kawamura[SUP] 1 [/SUP], Yuki Higashimoto[SUP] 2 [/SUP], Hiroki Miura[SUP] 1 [/SUP], Masaru Ihira[SUP] 3 [/SUP], Masato Inaba[SUP] 4 [/SUP], Ryota Ito[SUP] 4 [/SUP], Kei Kozawa[SUP] 1 [/SUP], Tetsushi Yoshikawa[SUP] 1 [/SUP]
Affiliations
Abstract
Pediatric cases of the coronavirus disease 2019 (COVID-19) are generally mild or asymptomatic, and are usually detected by virological examination following close contact with COVID-19 patients, often the children's parents. The detailed clinical features and virological data of pediatric COVID-19 patients, particularly young infants, remain unclear. Here, the clinical and virological characteristics of 4 children with COVID-19 including two young infants were investigated. One- and 4-month-old boys with COVID-19 were both asymptomatic, and seroconversion was demonstrated. These findings suggest that even young infants can mount an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), despite having weaker immune defenses than adolescents and adults. Three-year-old boy, who was SARS-CoV-2-negative, was admitted to the same room as his SARS-CoV-2-positive father due to the lack of caregivers. Although he was asymptomatic, he had seroconverted to SARS-CoV-2. Eleven-year-old boy, who was sibling of the 3-year-old boy, was also SARS-CoV-2-negative. He was isolated in his own room and did not seroconvert. If young children are SARS-CoV-2 negative, they should be isolated from their SARS-CoV-2-positive parents. This may be difficult in practice, if parents with COVID-19 are the only available caregivers. In such situations, the most appropriate measures should be taken for each patient. This article is protected by copyright. All rights reserved.
Keywords: antibodies; coronavirus disease 2019; infants; severe acute respiratory syndrome coronavirus 2.
. 2020 Sep 8.
doi: 10.1002/jmv.26493. Online ahead of print.
Immune response against SARS-CoV-2 in pediatric patients including young infants
Yoshiki Kawamura[SUP] 1 [/SUP], Yuki Higashimoto[SUP] 2 [/SUP], Hiroki Miura[SUP] 1 [/SUP], Masaru Ihira[SUP] 3 [/SUP], Masato Inaba[SUP] 4 [/SUP], Ryota Ito[SUP] 4 [/SUP], Kei Kozawa[SUP] 1 [/SUP], Tetsushi Yoshikawa[SUP] 1 [/SUP]
Affiliations
- PMID: 32897544
- DOI: 10.1002/jmv.26493
Abstract
Pediatric cases of the coronavirus disease 2019 (COVID-19) are generally mild or asymptomatic, and are usually detected by virological examination following close contact with COVID-19 patients, often the children's parents. The detailed clinical features and virological data of pediatric COVID-19 patients, particularly young infants, remain unclear. Here, the clinical and virological characteristics of 4 children with COVID-19 including two young infants were investigated. One- and 4-month-old boys with COVID-19 were both asymptomatic, and seroconversion was demonstrated. These findings suggest that even young infants can mount an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), despite having weaker immune defenses than adolescents and adults. Three-year-old boy, who was SARS-CoV-2-negative, was admitted to the same room as his SARS-CoV-2-positive father due to the lack of caregivers. Although he was asymptomatic, he had seroconverted to SARS-CoV-2. Eleven-year-old boy, who was sibling of the 3-year-old boy, was also SARS-CoV-2-negative. He was isolated in his own room and did not seroconvert. If young children are SARS-CoV-2 negative, they should be isolated from their SARS-CoV-2-positive parents. This may be difficult in practice, if parents with COVID-19 are the only available caregivers. In such situations, the most appropriate measures should be taken for each patient. This article is protected by copyright. All rights reserved.
Keywords: antibodies; coronavirus disease 2019; infants; severe acute respiratory syndrome coronavirus 2.