tetano
Editor, Senior Moderator
J Med Virol
. 2020 Oct 15.
doi: 10.1002/jmv.26601. Online ahead of print.
Impact on disease mortality of clinical, biological and virological characteristics at hospital admission and over time in COVID-19 patients
Yazdan Yazdanpanah[SUP] 1 2 [/SUP], French COVID cohort study group
Affiliations
Abstract
Objectives: We conducted a multicentric prospective cohort of COVID-19 hospitalized patients to describe clinical, biological and virological characteristics at hospital admission and over time according to mortality up to Day 60 after admission.
Methods: For the analysis of risk factors of survival, analyses assessing associations between mortality and demographic characteristics or comorbidities were performed using a Cox regression model.
Results: Between January 24[SUP]th[/SUP] and March 15[SUP]th[/SUP] 2020, 246 patients with RT-PCR virologically-confirmed COVID-19 were enrolled. In multivariate analysis, mortality at Day 60 (n=42 patients, 17.1% [95%CI: 12.6 to 22.4]) was associated with older age (aHR for age ≥65 years: 5.22 [2.56 to 10.63, P<.001]), gender (aHR for male: 2.97 [1.47 to 5.99, P=.002]), chronic pulmonary disease (aHR: 4.84 [2.32 to 10.07, P<.001]), obesity (aHR: 3.32 [1.70 to 6.52, P<.001]) and diabetes (aHR: 1.98 [1.01 to 3.89, P=.048]).The median nasopharyngeal viral load at admission was 6.4 log[SUB]10[/SUB] copies/mL and was associated with mortality regardless of clinical risk factors. Viral load decreased with time elapsed since symptoms onset.
Conclusions: Mortality was associated with clinical characteristics at admission. The viral load at admission was significantly lower in patients admitted late after onset of symptoms in both dead and alive patients. This article is protected by copyright. All rights reserved.
. 2020 Oct 15.
doi: 10.1002/jmv.26601. Online ahead of print.
Impact on disease mortality of clinical, biological and virological characteristics at hospital admission and over time in COVID-19 patients
Yazdan Yazdanpanah[SUP] 1 2 [/SUP], French COVID cohort study group
Affiliations
- PMID: 33058220
- DOI: 10.1002/jmv.26601
Abstract
Objectives: We conducted a multicentric prospective cohort of COVID-19 hospitalized patients to describe clinical, biological and virological characteristics at hospital admission and over time according to mortality up to Day 60 after admission.
Methods: For the analysis of risk factors of survival, analyses assessing associations between mortality and demographic characteristics or comorbidities were performed using a Cox regression model.
Results: Between January 24[SUP]th[/SUP] and March 15[SUP]th[/SUP] 2020, 246 patients with RT-PCR virologically-confirmed COVID-19 were enrolled. In multivariate analysis, mortality at Day 60 (n=42 patients, 17.1% [95%CI: 12.6 to 22.4]) was associated with older age (aHR for age ≥65 years: 5.22 [2.56 to 10.63, P<.001]), gender (aHR for male: 2.97 [1.47 to 5.99, P=.002]), chronic pulmonary disease (aHR: 4.84 [2.32 to 10.07, P<.001]), obesity (aHR: 3.32 [1.70 to 6.52, P<.001]) and diabetes (aHR: 1.98 [1.01 to 3.89, P=.048]).The median nasopharyngeal viral load at admission was 6.4 log[SUB]10[/SUB] copies/mL and was associated with mortality regardless of clinical risk factors. Viral load decreased with time elapsed since symptoms onset.
Conclusions: Mortality was associated with clinical characteristics at admission. The viral load at admission was significantly lower in patients admitted late after onset of symptoms in both dead and alive patients. This article is protected by copyright. All rights reserved.