tetano
Editor, Senior Moderator
J Med Virol
. 2021 Jun 14.
doi: 10.1002/jmv.27132. Online ahead of print.
Molecular biology of the SARs-CoV-2 spike protein: A review of current knowledge
Chaogeng Zhu[SUP] 1 [/SUP], Guiyun He[SUP] 2 [/SUP], Qinqin Yin[SUP] 2 [/SUP], Lin Zeng[SUP] 3 [/SUP], Xiangli Ye[SUP] 4 [/SUP], Yongzhong Shi[SUP] 3 [/SUP], Wei Xu[SUP] 3 [/SUP]
Affiliations
Abstract
The global coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an unprecedented worldwide public health emergency. Despite the concerted efforts of the scientific field, by April 25, 2021, SARS-CoV-2 had spread to over 192 countries/regions, causing more than 146 million confirmed cases including 31 million deaths. For now, an established treatment for patients with COVID-19 remains unavailable. The key to tackling this pandemic is to understand the mechanisms underlying its infectivity and pathogenicity. As a predominant focus, the coronavirus spike (S) protein is the key determinant of host range, infectivity, and pathogenesis. Thereby comprehensive understanding of the sophisticated structure of SARS-CoV-2 S protein may provide insights into possible intervention strategies to fight this ongoing global pandemic. Herein, we summarize the current knowledge of the molecular structural and functional features of SARS-CoV-2 S protein as well as recent updates on the cell entry mechanism of the SARS-CoV-2, paving the way for exploring more structure-guided strategies against SARS-CoV-2.
Keywords: COVID-19; angiotensin-converting enzyme 2 (ACE2); coronavirus; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); spike Protein.
. 2021 Jun 14.
doi: 10.1002/jmv.27132. Online ahead of print.
Molecular biology of the SARs-CoV-2 spike protein: A review of current knowledge
Chaogeng Zhu[SUP] 1 [/SUP], Guiyun He[SUP] 2 [/SUP], Qinqin Yin[SUP] 2 [/SUP], Lin Zeng[SUP] 3 [/SUP], Xiangli Ye[SUP] 4 [/SUP], Yongzhong Shi[SUP] 3 [/SUP], Wei Xu[SUP] 3 [/SUP]
Affiliations
- PMID: 34125455
- DOI: 10.1002/jmv.27132
Abstract
The global coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an unprecedented worldwide public health emergency. Despite the concerted efforts of the scientific field, by April 25, 2021, SARS-CoV-2 had spread to over 192 countries/regions, causing more than 146 million confirmed cases including 31 million deaths. For now, an established treatment for patients with COVID-19 remains unavailable. The key to tackling this pandemic is to understand the mechanisms underlying its infectivity and pathogenicity. As a predominant focus, the coronavirus spike (S) protein is the key determinant of host range, infectivity, and pathogenesis. Thereby comprehensive understanding of the sophisticated structure of SARS-CoV-2 S protein may provide insights into possible intervention strategies to fight this ongoing global pandemic. Herein, we summarize the current knowledge of the molecular structural and functional features of SARS-CoV-2 S protein as well as recent updates on the cell entry mechanism of the SARS-CoV-2, paving the way for exploring more structure-guided strategies against SARS-CoV-2.
Keywords: COVID-19; angiotensin-converting enzyme 2 (ACE2); coronavirus; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); spike Protein.