tetano
Editor, Senior Moderator
J Med Virol
. 2023 Jul;95(7):e28971.
doi: 10.1002/jmv.28971. Outpatient atorvastatin use and severe COVID-19 outcomes: A population-based study
Irene Visos-Varela[SUP] 1 [/SUP], Maruxa Zapata-Cachafeiro[SUP] 1 2 3 [/SUP], Samuel Pintos-Rodríguez[SUP] 1 [/SUP], Rosendo Bugarín-González[SUP] 4 [/SUP], Francisco Javier González-Barcala[SUP] 5 6 [/SUP], Maria T Herdeiro[SUP] 7 [/SUP], María Piñeiro-Lamas[SUP] 3 [/SUP], Adolfo Figueiras[SUP] 1 2 3 [/SUP], Ángel Salgado-Barreira[SUP] 1 2 3 [/SUP]
Affiliations
Evidence of the effect of statins on patients with coronavirus disease (2019) COVID-19 is inconsistent. The aim of this study was to evaluate the association between chronic use of statins-both overall and by active ingredient-and severe outcomes of COVID-19 (risk of hospitalization and mortality), progression to severe outcomes, and susceptibility to the virus. We conducted a population-based case-control study with data from electronic records to assess the risk of (1) hospitalization: cases were patients admitted due to COVID-19 and controls were subjects without COVID-19; (2) mortality: cases were hospitalized patients who died due to COVID-19 and controls were subjects without COVID-19; (3) progression: cases were hospitalized COVID-19 subjects and controls were nonhospitalized COVID-19 patients; and (4) susceptibility: cases were patients with COVID-19 (both hospitalized and nonhospitalized) and controls were subjects without COVID-19. We collected data on 2821 hospitalized cases, 26 996 nonhospitalized cases, and 52 318 controls. Chronic use of atorvastatin was associated with a decreased risk of hospitalization (adjusted odds ratios [aOR] = 0.83; 95% confidence interval [CI]: 0.74-0.92) and mortality (aOR = 0.70; 95% CI: 0.53-0.93), attributable in part to a lower risk of susceptibility to the virus (aOR = 0.91; 95% CI: 0.86-0.96). Simvastatin was associated with a reduced risk of mortality (aOR = 0.59; 95% CI: 0.40-0.87). The wide degree of heterogeneity observed in the estimated odds ratios (ORs) of the different statins suggests that there is no class effect. The results of this real-world study suggest that chronic use of atorvastatin (and to a lesser degree, of simvastatin) is associated with a decrease in risk of severe COVID-19 outcomes.
Keywords: COVID-19; atorvastatin; hospitalization; mortality; outpatient; statins.
. 2023 Jul;95(7):e28971.
doi: 10.1002/jmv.28971. Outpatient atorvastatin use and severe COVID-19 outcomes: A population-based study
Irene Visos-Varela[SUP] 1 [/SUP], Maruxa Zapata-Cachafeiro[SUP] 1 2 3 [/SUP], Samuel Pintos-Rodríguez[SUP] 1 [/SUP], Rosendo Bugarín-González[SUP] 4 [/SUP], Francisco Javier González-Barcala[SUP] 5 6 [/SUP], Maria T Herdeiro[SUP] 7 [/SUP], María Piñeiro-Lamas[SUP] 3 [/SUP], Adolfo Figueiras[SUP] 1 2 3 [/SUP], Ángel Salgado-Barreira[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37486310
- DOI: 10.1002/jmv.28971
Evidence of the effect of statins on patients with coronavirus disease (2019) COVID-19 is inconsistent. The aim of this study was to evaluate the association between chronic use of statins-both overall and by active ingredient-and severe outcomes of COVID-19 (risk of hospitalization and mortality), progression to severe outcomes, and susceptibility to the virus. We conducted a population-based case-control study with data from electronic records to assess the risk of (1) hospitalization: cases were patients admitted due to COVID-19 and controls were subjects without COVID-19; (2) mortality: cases were hospitalized patients who died due to COVID-19 and controls were subjects without COVID-19; (3) progression: cases were hospitalized COVID-19 subjects and controls were nonhospitalized COVID-19 patients; and (4) susceptibility: cases were patients with COVID-19 (both hospitalized and nonhospitalized) and controls were subjects without COVID-19. We collected data on 2821 hospitalized cases, 26 996 nonhospitalized cases, and 52 318 controls. Chronic use of atorvastatin was associated with a decreased risk of hospitalization (adjusted odds ratios [aOR] = 0.83; 95% confidence interval [CI]: 0.74-0.92) and mortality (aOR = 0.70; 95% CI: 0.53-0.93), attributable in part to a lower risk of susceptibility to the virus (aOR = 0.91; 95% CI: 0.86-0.96). Simvastatin was associated with a reduced risk of mortality (aOR = 0.59; 95% CI: 0.40-0.87). The wide degree of heterogeneity observed in the estimated odds ratios (ORs) of the different statins suggests that there is no class effect. The results of this real-world study suggest that chronic use of atorvastatin (and to a lesser degree, of simvastatin) is associated with a decrease in risk of severe COVID-19 outcomes.
Keywords: COVID-19; atorvastatin; hospitalization; mortality; outpatient; statins.