tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jan 14.
doi: 10.1002/jmv.27586. Online ahead of print.
Post-sequelae symptoms and comorbidities after COVID-19
Priya Duggal[SUP] 1 2 [/SUP], Tristan Penson[SUP] 2 [/SUP], Hannah N Manley[SUP] 1 [/SUP], Candelaria Vergara[SUP] 1 [/SUP], Rebecca M Munday[SUP] 3 [/SUP], Dylan Duchen[SUP] 1 [/SUP], Elizabeth A Linton[SUP] 1 [/SUP], Amber Zurn[SUP] 1 [/SUP], Jeanne C Keruly[SUP] 2 [/SUP], Shruti H Mehta[SUP] 1 2 [/SUP], David L Thomas[SUP] 1 2 [/SUP]
Affiliations
Abstract
Background: The frequency, severity, and forms of symptoms months after coronavirus 2019 (COVID-19) are poorly understood, especially in community settings.
Objective: To characterize symptoms months after community-based COVID-19.
Design: Retrospective cohort analysis.
Setting: Persons testing positive for SARS-CoV-2 RNA in the Johns Hopkins Health System, Maryland.
Patients: 328 consecutive persons with a positive test for SARS-CoV-2 March-May 2020.
Measurements: symptom occurrence and severity by administered questionnaire.
Results: Of 328 persons evaluated a median of 242 days (109 to 478 days) from initial positive SARS-CoV-2 test, 33.2% reported not being fully recovered and 4.9% reported symptoms that constrained daily activities. Compared to those who reported being fully recovered, those with post-acute sequelae were more likely to report a prior history of heart attack (p<0.01. Among those reporting long-term symptoms, men and women were equally represented (men= 34.8%, women= 34.6%), but only women reported symptoms that constrained daily activities, and 56% of them were caregivers. The types of new or persistent symptoms varied, and for many, included a deviation from prior COVID-19 health, such as being less able to exercise, walk, concentrate, or breathe.
Limitation: Self-report of symptoms might be biased and/or caused by factors other than COVID-19.
Conclusion: Even in a community setting, symptoms may persist months after COVID-19 reducing daily activities including caring for dependents. This article is protected by copyright. All rights reserved.
Keywords: Post-COVID-19; SARS-CoV-2; long-haul; sequela.
. 2022 Jan 14.
doi: 10.1002/jmv.27586. Online ahead of print.
Post-sequelae symptoms and comorbidities after COVID-19
Priya Duggal[SUP] 1 2 [/SUP], Tristan Penson[SUP] 2 [/SUP], Hannah N Manley[SUP] 1 [/SUP], Candelaria Vergara[SUP] 1 [/SUP], Rebecca M Munday[SUP] 3 [/SUP], Dylan Duchen[SUP] 1 [/SUP], Elizabeth A Linton[SUP] 1 [/SUP], Amber Zurn[SUP] 1 [/SUP], Jeanne C Keruly[SUP] 2 [/SUP], Shruti H Mehta[SUP] 1 2 [/SUP], David L Thomas[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35032030
- DOI: 10.1002/jmv.27586
Abstract
Background: The frequency, severity, and forms of symptoms months after coronavirus 2019 (COVID-19) are poorly understood, especially in community settings.
Objective: To characterize symptoms months after community-based COVID-19.
Design: Retrospective cohort analysis.
Setting: Persons testing positive for SARS-CoV-2 RNA in the Johns Hopkins Health System, Maryland.
Patients: 328 consecutive persons with a positive test for SARS-CoV-2 March-May 2020.
Measurements: symptom occurrence and severity by administered questionnaire.
Results: Of 328 persons evaluated a median of 242 days (109 to 478 days) from initial positive SARS-CoV-2 test, 33.2% reported not being fully recovered and 4.9% reported symptoms that constrained daily activities. Compared to those who reported being fully recovered, those with post-acute sequelae were more likely to report a prior history of heart attack (p<0.01. Among those reporting long-term symptoms, men and women were equally represented (men= 34.8%, women= 34.6%), but only women reported symptoms that constrained daily activities, and 56% of them were caregivers. The types of new or persistent symptoms varied, and for many, included a deviation from prior COVID-19 health, such as being less able to exercise, walk, concentrate, or breathe.
Limitation: Self-report of symptoms might be biased and/or caused by factors other than COVID-19.
Conclusion: Even in a community setting, symptoms may persist months after COVID-19 reducing daily activities including caring for dependents. This article is protected by copyright. All rights reserved.
Keywords: Post-COVID-19; SARS-CoV-2; long-haul; sequela.