tetano
Editor, Senior Moderator
J Med Virol
. 2021 Nov 29.
doi: 10.1002/jmv.27486. Online ahead of print.
SARS-CoV-2 antibody kinetics in blood donors with a previously positive SARS-CoV-2 antibody test within a seroprevalence survey
Mette Bøegh Levring[SUP] 1 [/SUP], Dorte Kinggaard Holm[SUP] 1 [/SUP], Anna Christine Nilsson[SUP] 1 [/SUP], Joschka Martin Bauer[SUP] 1 [/SUP], Iben Skov Jensen[SUP] 1 [/SUP], Jesper Rømhild Davidsen[SUP] 2 3 [/SUP], Line Dahlerup Rasmussen[SUP] 4 [/SUP], Ulrik Sprogøe[SUP] 1 [/SUP], Søren Thue Lillevang[SUP] 1 [/SUP]
Affiliations
Abstract
Persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is a matter of importance regarding the coronavirus disease 19 (COVID-19) pandemic. To observe antibody dynamics, 105 blood donors, positive for SARS-CoV-2 antibodies by a lateral flow test within a seroprevalence study, were included in this study. Thirty-nine (37%) of 105 the donors were confirmed positive by a total Ig Wantai ELISA. Three (8%) in this group of 39 reported severe and 26/39 (67%) mild to moderate COVID-19 symptoms. By further ELISA-testing, 33/39 (85%) donors were initially positive for IgG antibodies, 31/39 (79%) for IgA, and 32/39 (82%) for IgM, while 27/39 (69%) were positive for all three isotypes. Persistence of IgG, IgA, and IgM was observed in 73%, 79%, and 32% of donors, respectively, after 6-9 months observation. For IgM antibodies the decline in proportion of positive donors was statistically significant (p=0.002) during 12 months observation, for IgG only the decline at 3 months was statistically significant (p=0.042). Four donors exhibited notable increases in antibody levels. In conclusion, persistent SARS-CoV-2 IgA antibodies and IgG antibodies at 6-9 months are present in approximately 3 of 4 individuals with previous mild to moderate COVID-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Lateral Flow Test; SARS-CoV-2; antibody; blood donors.
. 2021 Nov 29.
doi: 10.1002/jmv.27486. Online ahead of print.
SARS-CoV-2 antibody kinetics in blood donors with a previously positive SARS-CoV-2 antibody test within a seroprevalence survey
Mette Bøegh Levring[SUP] 1 [/SUP], Dorte Kinggaard Holm[SUP] 1 [/SUP], Anna Christine Nilsson[SUP] 1 [/SUP], Joschka Martin Bauer[SUP] 1 [/SUP], Iben Skov Jensen[SUP] 1 [/SUP], Jesper Rømhild Davidsen[SUP] 2 3 [/SUP], Line Dahlerup Rasmussen[SUP] 4 [/SUP], Ulrik Sprogøe[SUP] 1 [/SUP], Søren Thue Lillevang[SUP] 1 [/SUP]
Affiliations
- PMID: 34845745
- DOI: 10.1002/jmv.27486
Abstract
Persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is a matter of importance regarding the coronavirus disease 19 (COVID-19) pandemic. To observe antibody dynamics, 105 blood donors, positive for SARS-CoV-2 antibodies by a lateral flow test within a seroprevalence study, were included in this study. Thirty-nine (37%) of 105 the donors were confirmed positive by a total Ig Wantai ELISA. Three (8%) in this group of 39 reported severe and 26/39 (67%) mild to moderate COVID-19 symptoms. By further ELISA-testing, 33/39 (85%) donors were initially positive for IgG antibodies, 31/39 (79%) for IgA, and 32/39 (82%) for IgM, while 27/39 (69%) were positive for all three isotypes. Persistence of IgG, IgA, and IgM was observed in 73%, 79%, and 32% of donors, respectively, after 6-9 months observation. For IgM antibodies the decline in proportion of positive donors was statistically significant (p=0.002) during 12 months observation, for IgG only the decline at 3 months was statistically significant (p=0.042). Four donors exhibited notable increases in antibody levels. In conclusion, persistent SARS-CoV-2 IgA antibodies and IgG antibodies at 6-9 months are present in approximately 3 of 4 individuals with previous mild to moderate COVID-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Lateral Flow Test; SARS-CoV-2; antibody; blood donors.