tetano
Editor, Senior Moderator
J Med Virol
. 2021 Feb 17.
doi: 10.1002/jmv.26883. Online ahead of print.
SARS-CoV-2 infection affects the lower urinary tract and male genital system: a systematic review
Massimiliano Creta[SUP] 1 [/SUP], Caterina Sagnelli[SUP] 2 [/SUP], Giuseppe Celentano[SUP] 1 [/SUP], Luigi Napolitano[SUP] 1 [/SUP], Roberto La Rocca[SUP] 1 [/SUP], Marco Capece[SUP] 1 [/SUP], Gianluigi Califano[SUP] 1 [/SUP], Armando Calogero[SUP] 3 [/SUP], Antonello Sica[SUP] 4 [/SUP], Francesco Mangiapia[SUP] 1 [/SUP], Massimo Ciccozzi[SUP] 5 [/SUP], Ferdinando Fusco[SUP] 6 [/SUP], Vincenzo Mirone[SUP] 1 [/SUP], Evangelista Sagnelli[SUP] 2 [/SUP], Nicola Longo[SUP] 1 [/SUP]
Affiliations
Abstract
PubMed, Scopus, and ISI Web of Knowledge databases were searched to identify studies published up to December 2020 on the involvement of urinary and male genital systems in COVID-19. Sixteen studies involving a total of 575 patients (538 males and 37 females) were included in this systematic review. The COVID-19 phase was available for 479 patients: 426 in the acute and 53 in the recovery phase. De novo lower urinary tract symptoms (LUTS) were observed in 43 patients and deterioration of preexisting LUTS in 7. Bladder hemorrhage was observed in 3 patients and acute urinary retention in one. Regarding male genital system, scrotal discomfort was observed in 8 patients, swelling in 14, pain in 16, and erythema in one; low flow priapism was observed in 2 patients. Ultrasound examination identified acute orchitis in 10 patients, acute epididymitis in 7, and acute epididymo-orchitis in 16. A case-control study reported that patients with moderate COVID-19 show a significant reduction in sperm concertation, total number of sperms per ejaculate, progressive motility, and complete motility. Contrary to what known from the first studies on the subject, this review also including subsequent studies give evidence of an involvement of lower urinary tract and male genital system in COVID-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Coronavirus; Disease control; Genital tract; Infection; SARS-CoV-2; Urinary tract.
. 2021 Feb 17.
doi: 10.1002/jmv.26883. Online ahead of print.
SARS-CoV-2 infection affects the lower urinary tract and male genital system: a systematic review
Massimiliano Creta[SUP] 1 [/SUP], Caterina Sagnelli[SUP] 2 [/SUP], Giuseppe Celentano[SUP] 1 [/SUP], Luigi Napolitano[SUP] 1 [/SUP], Roberto La Rocca[SUP] 1 [/SUP], Marco Capece[SUP] 1 [/SUP], Gianluigi Califano[SUP] 1 [/SUP], Armando Calogero[SUP] 3 [/SUP], Antonello Sica[SUP] 4 [/SUP], Francesco Mangiapia[SUP] 1 [/SUP], Massimo Ciccozzi[SUP] 5 [/SUP], Ferdinando Fusco[SUP] 6 [/SUP], Vincenzo Mirone[SUP] 1 [/SUP], Evangelista Sagnelli[SUP] 2 [/SUP], Nicola Longo[SUP] 1 [/SUP]
Affiliations
- PMID: 33595134
- DOI: 10.1002/jmv.26883
Abstract
PubMed, Scopus, and ISI Web of Knowledge databases were searched to identify studies published up to December 2020 on the involvement of urinary and male genital systems in COVID-19. Sixteen studies involving a total of 575 patients (538 males and 37 females) were included in this systematic review. The COVID-19 phase was available for 479 patients: 426 in the acute and 53 in the recovery phase. De novo lower urinary tract symptoms (LUTS) were observed in 43 patients and deterioration of preexisting LUTS in 7. Bladder hemorrhage was observed in 3 patients and acute urinary retention in one. Regarding male genital system, scrotal discomfort was observed in 8 patients, swelling in 14, pain in 16, and erythema in one; low flow priapism was observed in 2 patients. Ultrasound examination identified acute orchitis in 10 patients, acute epididymitis in 7, and acute epididymo-orchitis in 16. A case-control study reported that patients with moderate COVID-19 show a significant reduction in sperm concertation, total number of sperms per ejaculate, progressive motility, and complete motility. Contrary to what known from the first studies on the subject, this review also including subsequent studies give evidence of an involvement of lower urinary tract and male genital system in COVID-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Coronavirus; Disease control; Genital tract; Infection; SARS-CoV-2; Urinary tract.