tetano
Editor, Senior Moderator
J Med Virol
. 2021 Feb 27.
doi: 10.1002/jmv.26911. Online ahead of print.
Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2
Asim Zahoor Abbasi[SUP] 1 [/SUP], Dania Akram Kiyani[SUP] 1 [/SUP], Syeda Maira Hamid[SUP] 1 [/SUP], Muhammad Saalim[SUP] 2 3 [/SUP], Ammad Fahim[SUP] 4 [/SUP], Nasir Jalal[SUP] 5 6 [/SUP]
Affiliations
Abstract
Epidemiological data shows discrepancy in COVID-19 susceptibility and outcomes with some regions being more heavily affected than others. However, the factors that determine host susceptibility and pathogenicity remain elusive. Increasing number of publications highlight the role of Transmembrane Serine Protease 2 (TMPRSS2) in the susceptibility of host cell to SARS-CoV-2. Cleavage of viral spike protein via the host cell's TMPRSS2 enzyme activity mediates viral entry into the host cell. The enzyme synthesis is regulated by TMPRSS2 gene, which has also been implicated in the entry mechanisms of previously reported Coronavirus infections. In this review we have investigated the pathogenicity of SARS-CoV-2 and disease susceptibility dependence on TMPRSS2 gene as expressed in various population groups. We further discuss how the differential expression of this gene in various ethnic groups can affect the SARS-CoV-2 infection and Coronavirus disease (COVID)-19 outcomes. Moreover, promising new TMPRSS2 protease blockers and inhibitors are discussed for COVID-19 treatment. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Coronavirus; Differential gene expression; SARS-CoV-2; TMPRSS2; TMPRSS2 Blockers; TMPRSS2 Inhibitors; Viral entry.
. 2021 Feb 27.
doi: 10.1002/jmv.26911. Online ahead of print.
Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2
Asim Zahoor Abbasi[SUP] 1 [/SUP], Dania Akram Kiyani[SUP] 1 [/SUP], Syeda Maira Hamid[SUP] 1 [/SUP], Muhammad Saalim[SUP] 2 3 [/SUP], Ammad Fahim[SUP] 4 [/SUP], Nasir Jalal[SUP] 5 6 [/SUP]
Affiliations
- PMID: 33638460
- DOI: 10.1002/jmv.26911
Abstract
Epidemiological data shows discrepancy in COVID-19 susceptibility and outcomes with some regions being more heavily affected than others. However, the factors that determine host susceptibility and pathogenicity remain elusive. Increasing number of publications highlight the role of Transmembrane Serine Protease 2 (TMPRSS2) in the susceptibility of host cell to SARS-CoV-2. Cleavage of viral spike protein via the host cell's TMPRSS2 enzyme activity mediates viral entry into the host cell. The enzyme synthesis is regulated by TMPRSS2 gene, which has also been implicated in the entry mechanisms of previously reported Coronavirus infections. In this review we have investigated the pathogenicity of SARS-CoV-2 and disease susceptibility dependence on TMPRSS2 gene as expressed in various population groups. We further discuss how the differential expression of this gene in various ethnic groups can affect the SARS-CoV-2 infection and Coronavirus disease (COVID)-19 outcomes. Moreover, promising new TMPRSS2 protease blockers and inhibitors are discussed for COVID-19 treatment. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Coronavirus; Differential gene expression; SARS-CoV-2; TMPRSS2; TMPRSS2 Blockers; TMPRSS2 Inhibitors; Viral entry.