tetano
Editor, Senior Moderator
J Med Virol
. 2022 Feb 16.
doi: 10.1002/jmv.27663. Online ahead of print.
The SARS-CoV-2 mu variant shouldn't be left aside: it warrants attention for its immuo-escaping ability
Stefano Pascarella[SUP] 1 [/SUP], Martina Bianchi[SUP] 1 [/SUP], Marta Giovanetti[SUP] 2 3 4 [/SUP], Daniele Narzi[SUP] 5 [/SUP], Roberto Cauda[SUP] 6 [/SUP], Antonio Cassone[SUP] 7 [/SUP], Massimo Ciccozzi[SUP] 8 [/SUP]
Affiliations
Abstract
The COVID-19 pandemic continues to have a threatening impact on a global scale, largely due to the emergence of newly SARS-CoV-2 variants. The Mu (PANGO lineage B.1.621), was first identified in Colombia in January 2021 and was classified as a variant of interest (VOI) in August 2021, due to a constellation of mutations that likely-mediate an unexpectedly enhanced immune resistance to inactivated vaccine-elicited antibodies. Despite if recently studies suggested that the Mu variant appear to have a less infectivity than the Delta variant, here we examined the structural effect of the Mu spike protein mutations and predicted the potential impact on infectivity of the Mu variant compared with the Delta and Delta plus spike protein. This article is protected by copyright. All rights reserved.
Keywords: Antigenic variation; Biostatistics & Bioinformatics; Genetics; SARS coronavirus; Virus classification.
. 2022 Feb 16.
doi: 10.1002/jmv.27663. Online ahead of print.
The SARS-CoV-2 mu variant shouldn't be left aside: it warrants attention for its immuo-escaping ability
Stefano Pascarella[SUP] 1 [/SUP], Martina Bianchi[SUP] 1 [/SUP], Marta Giovanetti[SUP] 2 3 4 [/SUP], Daniele Narzi[SUP] 5 [/SUP], Roberto Cauda[SUP] 6 [/SUP], Antonio Cassone[SUP] 7 [/SUP], Massimo Ciccozzi[SUP] 8 [/SUP]
Affiliations
- PMID: 35174519
- DOI: 10.1002/jmv.27663
Abstract
The COVID-19 pandemic continues to have a threatening impact on a global scale, largely due to the emergence of newly SARS-CoV-2 variants. The Mu (PANGO lineage B.1.621), was first identified in Colombia in January 2021 and was classified as a variant of interest (VOI) in August 2021, due to a constellation of mutations that likely-mediate an unexpectedly enhanced immune resistance to inactivated vaccine-elicited antibodies. Despite if recently studies suggested that the Mu variant appear to have a less infectivity than the Delta variant, here we examined the structural effect of the Mu spike protein mutations and predicted the potential impact on infectivity of the Mu variant compared with the Delta and Delta plus spike protein. This article is protected by copyright. All rights reserved.
Keywords: Antigenic variation; Biostatistics & Bioinformatics; Genetics; SARS coronavirus; Virus classification.