tetano
Editor, Senior Moderator
J Med Virol
. 2020 Nov 26.
doi: 10.1002/jmv.26698. Online ahead of print.
Tocilizumab administration is associated with reduction in biomarkers of coronavirus disease 2019 (COVID-19) infection
Timotius Ivan Hariyanto[SUP] 1 [/SUP], Andree Kurniawan[SUP] 2 [/SUP]
Affiliations
Abstract
Background and aims: Coronavirus disease 2019 (COVID-19) has caused a significant impact on all aspects of life with the number of death cases is still increasing. Therefore, identification of potential treatment for reducing the severity of the disease is important. Currently, the data regarding the effectivity of tocilizumab as treatment agents for COVID-19 infection is still conflicting. This study aims to give clear evidence regarding the potential benefit of tocilizumab in reducing the biomarkers of COVID-19 infection.
Methods: We systematically searched the PubMed Central database using specific keywords related to our aims until July 24[SUP]th[/SUP] , 2020. All articles published on COVID-19 and tocilizumab were retrieved.
Results: A total of 9 studies with a total of 577 patients were included in our analysis. Our meta-analysis showed that tocilizumab treatment is associated with reduction of CRP [MD -106.69 mg/L (95% CI -146.90, -66.49 mg/L), p < 0.00001; I[SUP]2[/SUP] = 98%, random-effect modelling], D-Dimer [MD -3.06 mg/L (95% CI -5.81, -0.31 mg/L), p = 0.03; I[SUP]2[/SUP] = 98%, random-effect modelling], Ferritin [MD -532.80 ng/mL (95% CI -810.93, -254.67 ng/mL), p = 0.0002; I[SUP]2[/SUP] = 25%, random-effect modelling], PCT [MD -0.67 ng/mL (95% CI -1.13, -0.22 ng/mL), p = 0.004; I[SUP]2[/SUP] = 92%, random-effect modelling], and increment in the levels of Lymphocyte count [MD 0.36 x 10[SUP]3[/SUP] /μL (95% CI 0.18, 0.54 x 10[SUP]3[/SUP] /μL), p < 0.0001; I[SUP]2[/SUP] = 88%, random-effect modelling].
Conclusion: Administration of tocilizumab is effective in reducing the biomarkers of the COVID-19 infection. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; coronavirus disease 2019; immunomodulator; interleukin-6; tocilizumab
. 2020 Nov 26.
doi: 10.1002/jmv.26698. Online ahead of print.
Tocilizumab administration is associated with reduction in biomarkers of coronavirus disease 2019 (COVID-19) infection
Timotius Ivan Hariyanto[SUP] 1 [/SUP], Andree Kurniawan[SUP] 2 [/SUP]
Affiliations
- PMID: 33241872
- DOI: 10.1002/jmv.26698
Abstract
Background and aims: Coronavirus disease 2019 (COVID-19) has caused a significant impact on all aspects of life with the number of death cases is still increasing. Therefore, identification of potential treatment for reducing the severity of the disease is important. Currently, the data regarding the effectivity of tocilizumab as treatment agents for COVID-19 infection is still conflicting. This study aims to give clear evidence regarding the potential benefit of tocilizumab in reducing the biomarkers of COVID-19 infection.
Methods: We systematically searched the PubMed Central database using specific keywords related to our aims until July 24[SUP]th[/SUP] , 2020. All articles published on COVID-19 and tocilizumab were retrieved.
Results: A total of 9 studies with a total of 577 patients were included in our analysis. Our meta-analysis showed that tocilizumab treatment is associated with reduction of CRP [MD -106.69 mg/L (95% CI -146.90, -66.49 mg/L), p < 0.00001; I[SUP]2[/SUP] = 98%, random-effect modelling], D-Dimer [MD -3.06 mg/L (95% CI -5.81, -0.31 mg/L), p = 0.03; I[SUP]2[/SUP] = 98%, random-effect modelling], Ferritin [MD -532.80 ng/mL (95% CI -810.93, -254.67 ng/mL), p = 0.0002; I[SUP]2[/SUP] = 25%, random-effect modelling], PCT [MD -0.67 ng/mL (95% CI -1.13, -0.22 ng/mL), p = 0.004; I[SUP]2[/SUP] = 92%, random-effect modelling], and increment in the levels of Lymphocyte count [MD 0.36 x 10[SUP]3[/SUP] /μL (95% CI 0.18, 0.54 x 10[SUP]3[/SUP] /μL), p < 0.0001; I[SUP]2[/SUP] = 88%, random-effect modelling].
Conclusion: Administration of tocilizumab is effective in reducing the biomarkers of the COVID-19 infection. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; coronavirus disease 2019; immunomodulator; interleukin-6; tocilizumab