tetano
Editor, Senior Moderator
J Microbiol Immunol Infect
. 2022 Jul 16;S1684-1182(22)00101-3.
doi: 10.1016/j.jmii.2022.07.003. Online ahead of print.
Investigation of the diagnostic performance of the SARS-CoV-2 saliva antigen test: A meta-analysis
Cheng-Chieh Chen[SUP] 1 [/SUP], Ke-Yu Hsiao[SUP] 2 [/SUP], Chyi-Huey Bai[SUP] 3 [/SUP], Yuan-Hung Wang[SUP] 4 [/SUP]
Affiliations
Abstract
Background: The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rapid identification and isolation of patients with COVID-19 are critical strategies to contain COVID-19. The saliva antigen test has the advantages of noninvasiveness and decreased transmission risk to health-care professionals. This meta-analysis investigated the diagnostic accuracy of the saliva antigen test for SARS-CoV-2.
Methods: We searched for relevant studies in PubMed, Embase, Cochrane Library, and Biomed Central. Studies evaluating the diagnostic accuracy of saliva antigen tests for SARS-CoV-2 were included. The data of the included studies were used to construct a 2 × 2 table on a per patient basis. The overall sensitivity and specificity of saliva antigen tests were determined using a bivariate random-effects model.
Results: Nine studies enrolling 9842 patients were included. The meta-analysis generated a pooled sensitivity of 65.3% and a pooled specificity of 99.7%. A subgroup analysis of the studies performing the chemiluminescent enzyme immunoassay (CLEIA) for participants from airports and public health centers revealed a pooled sensitivity of 93.6%.
Conclusion: Our findings demonstrated that the saliva antigen test performed using CLEIA exhibited higher sensitivity for the detection of SARS-CoV-2. Therefore, the saliva antigen test performed using CLEIA might be an effective and noninvasive screening tool for SARS-CoV-2.
Keywords: Antigen test; COVID-19; Meta-Analysis; SARS-CoV-2; Saliva.
. 2022 Jul 16;S1684-1182(22)00101-3.
doi: 10.1016/j.jmii.2022.07.003. Online ahead of print.
Investigation of the diagnostic performance of the SARS-CoV-2 saliva antigen test: A meta-analysis
Cheng-Chieh Chen[SUP] 1 [/SUP], Ke-Yu Hsiao[SUP] 2 [/SUP], Chyi-Huey Bai[SUP] 3 [/SUP], Yuan-Hung Wang[SUP] 4 [/SUP]
Affiliations
- PMID: 35922266
- DOI: 10.1016/j.jmii.2022.07.003
Abstract
Background: The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rapid identification and isolation of patients with COVID-19 are critical strategies to contain COVID-19. The saliva antigen test has the advantages of noninvasiveness and decreased transmission risk to health-care professionals. This meta-analysis investigated the diagnostic accuracy of the saliva antigen test for SARS-CoV-2.
Methods: We searched for relevant studies in PubMed, Embase, Cochrane Library, and Biomed Central. Studies evaluating the diagnostic accuracy of saliva antigen tests for SARS-CoV-2 were included. The data of the included studies were used to construct a 2 × 2 table on a per patient basis. The overall sensitivity and specificity of saliva antigen tests were determined using a bivariate random-effects model.
Results: Nine studies enrolling 9842 patients were included. The meta-analysis generated a pooled sensitivity of 65.3% and a pooled specificity of 99.7%. A subgroup analysis of the studies performing the chemiluminescent enzyme immunoassay (CLEIA) for participants from airports and public health centers revealed a pooled sensitivity of 93.6%.
Conclusion: Our findings demonstrated that the saliva antigen test performed using CLEIA exhibited higher sensitivity for the detection of SARS-CoV-2. Therefore, the saliva antigen test performed using CLEIA might be an effective and noninvasive screening tool for SARS-CoV-2.
Keywords: Antigen test; COVID-19; Meta-Analysis; SARS-CoV-2; Saliva.