tetano
Editor, Senior Moderator
J Microbiol
. 2021 Sep;59(9):807-818.
doi: 10.1007/s12275-021-1348-5. Epub 2021 Aug 27.
The rapid adaptation of SARS-CoV-2-rise of the variants: transmission and resistance
Sandrine M Soh[SUP] 1 [/SUP], Yeongjun Kim[SUP] 1 [/SUP], Chanwoo Kim[SUP] 1 [/SUP], Ui Soon Jang[SUP] 1 [/SUP], Hye-Ra Lee[SUP] 2 3 [/SUP]
Affiliations
Abstract
The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating. Interestingly, identified mutations mainly occur in the spike (S) protein which interacts with the ACE2 receptor and is cleaved via serine protease TMPRSS2. Some mutated strains are becoming dominant in various parts of the globe because of increased transmissibility as well as cell entry efficacy. Remarkably, the neutralizing activity of monoclonal antibodies, convalescent sera, and vaccines against the variants has been reported to be significantly reduced. Therefore, the efficacy of various monoclonal antibodies therapy and vaccines against these variants is becoming a great global concern. We herein summarize the current status of SARS-CoV-2 with gears shifted towards the recent and most common genetic variants in relation to transmission, neutralizing activity, and vaccine efficacy.
Keywords: SARS-CoV-2; monoclonal antibodies; neutralization; transmission; vaccine; variants.
. 2021 Sep;59(9):807-818.
doi: 10.1007/s12275-021-1348-5. Epub 2021 Aug 27.
The rapid adaptation of SARS-CoV-2-rise of the variants: transmission and resistance
Sandrine M Soh[SUP] 1 [/SUP], Yeongjun Kim[SUP] 1 [/SUP], Chanwoo Kim[SUP] 1 [/SUP], Ui Soon Jang[SUP] 1 [/SUP], Hye-Ra Lee[SUP] 2 3 [/SUP]
Affiliations
- PMID: 34449057
- PMCID: PMC8390340
- DOI: 10.1007/s12275-021-1348-5
Abstract
The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating. Interestingly, identified mutations mainly occur in the spike (S) protein which interacts with the ACE2 receptor and is cleaved via serine protease TMPRSS2. Some mutated strains are becoming dominant in various parts of the globe because of increased transmissibility as well as cell entry efficacy. Remarkably, the neutralizing activity of monoclonal antibodies, convalescent sera, and vaccines against the variants has been reported to be significantly reduced. Therefore, the efficacy of various monoclonal antibodies therapy and vaccines against these variants is becoming a great global concern. We herein summarize the current status of SARS-CoV-2 with gears shifted towards the recent and most common genetic variants in relation to transmission, neutralizing activity, and vaccine efficacy.
Keywords: SARS-CoV-2; monoclonal antibodies; neutralization; transmission; vaccine; variants.