tetano
Editor, Senior Moderator
J Neuroimaging
. 2023 Jun 28.
doi: 10.1111/jon.13140. Online ahead of print. Neuroimaging findings in 4342 hospitalized COVID-19 subjects: A multicenter report from the United States and Europe
Scott H Faro[SUP] 1 [/SUP], Arichena Manmatharayan[SUP] 1 [/SUP], Benjamin Leiby[SUP] 1 [/SUP], Neelu Jain[SUP] 1 2 [/SUP], Feroze B Mohamed[SUP] 1 [/SUP], Kiran S Talekar[SUP] 1 [/SUP], Amish Doshi[SUP] 3 [/SUP], Ivan Jambor[SUP] 3 [/SUP], Sanders Chang[SUP] 3 [/SUP], Mark Finkelstein[SUP] 3 [/SUP], Stephane Kremer[SUP] 4 [/SUP], Francois Lersy[SUP] 4 [/SUP], Brenden Lindgren[SUP] 2 [/SUP], Nathalia M Figueiredo[SUP] 2 [/SUP], Simonetta Gerevini[SUP] 5 [/SUP], Angela Napolitano[SUP] 5 [/SUP], Rajan Jain[SUP] 6 [/SUP], Siddhanth Dogra[SUP] 6 [/SUP], Jay Pillai[SUP] 7 [/SUP], Dan Ryan[SUP] 7 [/SUP], Rolf Jager[SUP] 8 [/SUP], Francesco Carletti[SUP] 8 [/SUP], Asim Mian[SUP] 9 [/SUP], Artem Kaliev[SUP] 9 [/SUP], Pria Anand[SUP] 9 [/SUP], Courtney Takahashi[SUP] 9 [/SUP], Ak Murat[SUP] 10 [/SUP], Rivka Colen[SUP] 10 [/SUP], Giancarlo Mansueto[SUP] 11 [/SUP], Francesca Pizzini[SUP] 11 [/SUP]
Affiliations
Background and purpose: To determine the incidence of acute neuroimaging (NI) findings and comorbidities in the coronavirus disease of 2019 (COVID-19)-infected subjects in seven U.S. and four European hospitals.
Methods: This is a retrospective study of COVID-19-positive subjects with the following inclusion criteria: age >18, lab-confirmed COVID-19 infection, and acute NI findings (NI+) attributed to COVID-19 on CT or MRI brain. NI+ and comorbidities in total hospitalized COVID-19-positive (TN) subjects were assessed.
Results: A total of 37,950 COVID-19-positive subjects were reviewed and 4342 underwent NI. NI+ incidence in subjects with NI was 10.1% (442/4342) including 7.9% (294/3701) in the United States and 22.8% (148/647) in Europe. NI+ incidence in TN was 1.16% (442/37,950). In NI (4342), incidence of ischemic stroke was 6.4% followed by intracranial hemorrhage (ICH) (3.8%), encephalitis (0.5%), sinus venous thrombosis (0.2%), and acute disseminated encephalomyelitis (ADEM) (0.2%). White matter involvement was seen in 57% of NI+. Hypertension was the most common comorbidity (54%) before cardiac disease (28.8%) and diabetes mellitus (27.7%). Cardiac disease (p < .025), diabetes (p < .014), and chronic kidney disease (p < .012) were more common in the United States.
Conclusion: This multicenter, multinational study investigated the incidence and spectrum of NI+ in 37,950 hospitalized adult COVID-19 subjects including regional differences in incidences of NI+, associated comorbidities, and other demographics. NI+ incidence in TN was 1.16% including 0.95% in the United States and 2.09% in Europe. ICH, encephalitis, and ADEM were common in Europe, while ischemic strokes were more common in the United States. In this cohort, incidence and distribution of NI+ helped characterize the neurological complications of COVID-19.
Keywords: COVID-19; brain; neuroimaging.
. 2023 Jun 28.
doi: 10.1111/jon.13140. Online ahead of print. Neuroimaging findings in 4342 hospitalized COVID-19 subjects: A multicenter report from the United States and Europe
Scott H Faro[SUP] 1 [/SUP], Arichena Manmatharayan[SUP] 1 [/SUP], Benjamin Leiby[SUP] 1 [/SUP], Neelu Jain[SUP] 1 2 [/SUP], Feroze B Mohamed[SUP] 1 [/SUP], Kiran S Talekar[SUP] 1 [/SUP], Amish Doshi[SUP] 3 [/SUP], Ivan Jambor[SUP] 3 [/SUP], Sanders Chang[SUP] 3 [/SUP], Mark Finkelstein[SUP] 3 [/SUP], Stephane Kremer[SUP] 4 [/SUP], Francois Lersy[SUP] 4 [/SUP], Brenden Lindgren[SUP] 2 [/SUP], Nathalia M Figueiredo[SUP] 2 [/SUP], Simonetta Gerevini[SUP] 5 [/SUP], Angela Napolitano[SUP] 5 [/SUP], Rajan Jain[SUP] 6 [/SUP], Siddhanth Dogra[SUP] 6 [/SUP], Jay Pillai[SUP] 7 [/SUP], Dan Ryan[SUP] 7 [/SUP], Rolf Jager[SUP] 8 [/SUP], Francesco Carletti[SUP] 8 [/SUP], Asim Mian[SUP] 9 [/SUP], Artem Kaliev[SUP] 9 [/SUP], Pria Anand[SUP] 9 [/SUP], Courtney Takahashi[SUP] 9 [/SUP], Ak Murat[SUP] 10 [/SUP], Rivka Colen[SUP] 10 [/SUP], Giancarlo Mansueto[SUP] 11 [/SUP], Francesca Pizzini[SUP] 11 [/SUP]
Affiliations
- PMID: 37381160
- DOI: 10.1111/jon.13140
Background and purpose: To determine the incidence of acute neuroimaging (NI) findings and comorbidities in the coronavirus disease of 2019 (COVID-19)-infected subjects in seven U.S. and four European hospitals.
Methods: This is a retrospective study of COVID-19-positive subjects with the following inclusion criteria: age >18, lab-confirmed COVID-19 infection, and acute NI findings (NI+) attributed to COVID-19 on CT or MRI brain. NI+ and comorbidities in total hospitalized COVID-19-positive (TN) subjects were assessed.
Results: A total of 37,950 COVID-19-positive subjects were reviewed and 4342 underwent NI. NI+ incidence in subjects with NI was 10.1% (442/4342) including 7.9% (294/3701) in the United States and 22.8% (148/647) in Europe. NI+ incidence in TN was 1.16% (442/37,950). In NI (4342), incidence of ischemic stroke was 6.4% followed by intracranial hemorrhage (ICH) (3.8%), encephalitis (0.5%), sinus venous thrombosis (0.2%), and acute disseminated encephalomyelitis (ADEM) (0.2%). White matter involvement was seen in 57% of NI+. Hypertension was the most common comorbidity (54%) before cardiac disease (28.8%) and diabetes mellitus (27.7%). Cardiac disease (p < .025), diabetes (p < .014), and chronic kidney disease (p < .012) were more common in the United States.
Conclusion: This multicenter, multinational study investigated the incidence and spectrum of NI+ in 37,950 hospitalized adult COVID-19 subjects including regional differences in incidences of NI+, associated comorbidities, and other demographics. NI+ incidence in TN was 1.16% including 0.95% in the United States and 2.09% in Europe. ICH, encephalitis, and ADEM were common in Europe, while ischemic strokes were more common in the United States. In this cohort, incidence and distribution of NI+ helped characterize the neurological complications of COVID-19.
Keywords: COVID-19; brain; neuroimaging.