tetano
Editor, Senior Moderator
J Neuroimmunol
. 2020 Jul 14;346:577326.
doi: 10.1016/j.jneuroim.2020.577326. Online ahead of print.
Hemorrhagic encephalopathy associated with COVID-19
Jonathan D Krett[SUP] 1 [/SUP], Gordon A E Jewett[SUP] 2 [/SUP], Charissa Elton-Lacasse[SUP] 3 [/SUP], Kevin Fonseca[SUP] 4 [/SUP], Christopher Hahn[SUP] 2 [/SUP], Selena Au[SUP] 3 [/SUP], Marcus W Koch[SUP] 5 [/SUP]
Affiliations
Abstract
The mechanisms for neurological complications of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are not yet well understood. We present a critically ill man with a COVID-19-associated hemorrhagic encephalopathy. SARS-CoV-2 RNA was not detected in cerebrospinal fluid (CSF) or blood. CSF analyses suggested dysregulation of pro-inflammatory cytokine pathways, particularly tumor necrosis factor-α and interleukin-6, consistent with a cytokine release syndrome. The patient gradually recovered with supportive care and neurological rehabilitation. Awareness of this clinical entity may facilitate the identification of patients with a potentially remediable cause of encephalopathy in COVID-19.
Keywords: COVID-19; Coronavirus; Encephalopathy; Intracerebral hemorrhage; SARS-CoV-2.
. 2020 Jul 14;346:577326.
doi: 10.1016/j.jneuroim.2020.577326. Online ahead of print.
Hemorrhagic encephalopathy associated with COVID-19
Jonathan D Krett[SUP] 1 [/SUP], Gordon A E Jewett[SUP] 2 [/SUP], Charissa Elton-Lacasse[SUP] 3 [/SUP], Kevin Fonseca[SUP] 4 [/SUP], Christopher Hahn[SUP] 2 [/SUP], Selena Au[SUP] 3 [/SUP], Marcus W Koch[SUP] 5 [/SUP]
Affiliations
- PMID: 32683185
- DOI: 10.1016/j.jneuroim.2020.577326
Abstract
The mechanisms for neurological complications of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are not yet well understood. We present a critically ill man with a COVID-19-associated hemorrhagic encephalopathy. SARS-CoV-2 RNA was not detected in cerebrospinal fluid (CSF) or blood. CSF analyses suggested dysregulation of pro-inflammatory cytokine pathways, particularly tumor necrosis factor-α and interleukin-6, consistent with a cytokine release syndrome. The patient gradually recovered with supportive care and neurological rehabilitation. Awareness of this clinical entity may facilitate the identification of patients with a potentially remediable cause of encephalopathy in COVID-19.
Keywords: COVID-19; Coronavirus; Encephalopathy; Intracerebral hemorrhage; SARS-CoV-2.