tetano
Editor, Senior Moderator
J Neurol
. 2020 Sep 17.
doi: 10.1007/s00415-020-10219-5. Online ahead of print.
A rare case of acute motor axonal neuropathy and myelitis related to SARS-CoV-2 infection
Fabio Giuseppe Masuccio[SUP] 1 [/SUP], Massimo Barra[SUP] 2 [/SUP], Geda Claudio[SUP] 3 [/SUP], Solaro Claudio[SUP] 4 [/SUP]
Affiliations
Abstract
We describe a rare case of post-infective Acute Motor Axonal Neuropathy (AMAN) variant of Guillain-Barr? Syndrome (GBS) associated with myelitis and anti-GD1b positivity after SARS-CoV-2 infection. The patient referred to the hospital reporting a history of ten days lasting moderate fever, myalgia and anosmia, with the onset of progressive quadriparesis and ascending paraesthesias in the four limbs since five days from defervescence. A chest computed tomography demonstrated interstitial pneumonia with "ground glass opacities", suggesting Coronavirus disease (COVID-19). The patient exhibited three negative reverse-transcription polymerase chain reaction (RT-PCR) nasopharyngeal swabs, while SARS-CoV-2 IgG was found in plasma. The electrophysiological examination demonstrated an AMAN and the spinal cord Magnetic Resonance Imaging (MRI) showed a T2-weighted hyperintense lesion in the posterior part of the spinal cord at the C7-D1 levels. Furthermore, anti-GD1b IgM was detected. GBS and myelitis could exceptionally develop simultaneously. Our findings reasonably support a causality link between COVID-19 and the neurological symptoms, suggesting a post-infective autoimmune reaction.
Keywords: AMAN; Antiganglioside antibodies; Guillain-barr? syndrome; Myelitis; SARS-CoV-2.
. 2020 Sep 17.
doi: 10.1007/s00415-020-10219-5. Online ahead of print.
A rare case of acute motor axonal neuropathy and myelitis related to SARS-CoV-2 infection
Fabio Giuseppe Masuccio[SUP] 1 [/SUP], Massimo Barra[SUP] 2 [/SUP], Geda Claudio[SUP] 3 [/SUP], Solaro Claudio[SUP] 4 [/SUP]
Affiliations
- PMID: 32940797
- DOI: 10.1007/s00415-020-10219-5
Abstract
We describe a rare case of post-infective Acute Motor Axonal Neuropathy (AMAN) variant of Guillain-Barr? Syndrome (GBS) associated with myelitis and anti-GD1b positivity after SARS-CoV-2 infection. The patient referred to the hospital reporting a history of ten days lasting moderate fever, myalgia and anosmia, with the onset of progressive quadriparesis and ascending paraesthesias in the four limbs since five days from defervescence. A chest computed tomography demonstrated interstitial pneumonia with "ground glass opacities", suggesting Coronavirus disease (COVID-19). The patient exhibited three negative reverse-transcription polymerase chain reaction (RT-PCR) nasopharyngeal swabs, while SARS-CoV-2 IgG was found in plasma. The electrophysiological examination demonstrated an AMAN and the spinal cord Magnetic Resonance Imaging (MRI) showed a T2-weighted hyperintense lesion in the posterior part of the spinal cord at the C7-D1 levels. Furthermore, anti-GD1b IgM was detected. GBS and myelitis could exceptionally develop simultaneously. Our findings reasonably support a causality link between COVID-19 and the neurological symptoms, suggesting a post-infective autoimmune reaction.
Keywords: AMAN; Antiganglioside antibodies; Guillain-barr? syndrome; Myelitis; SARS-CoV-2.