tetano
Editor, Senior Moderator
J Nucl Med
. 2023 Aug 17;jnumed.123.265723.
doi: 10.2967/jnumed.123.265723. Online ahead of print. Total-Body Multiparametric PET Quantification of [SUP]18[/SUP]F-FDG Delivery and Metabolism in the Study of Coronavirus Disease 2019 Recovery
Yiran Wang[SUP] 1 2 [/SUP], Lorenzo Nardo[SUP] 3 [/SUP], Benjamin A Spencer[SUP] 3 2 [/SUP], Yasser G Abdelhafez[SUP] 3 4 [/SUP], Elizabeth J Li[SUP] 2 [/SUP], Negar Omidvari[SUP] 2 [/SUP], Abhijit J Chaudhari[SUP] 3 [/SUP], Ramsey D Badawi[SUP] 3 2 [/SUP], Terry Jones[SUP] 3 [/SUP], Simon R Cherry[SUP] 3 2 [/SUP], Guobao Wang[SUP] 3 [/SUP]
Affiliations
Conventional whole-body static [SUP]18[/SUP]F-FDG PET imaging provides a semiquantitative evaluation of overall glucose metabolism without insight into the specific transport and metabolic steps. Here we demonstrate the ability of total-body multiparametric [SUP]18[/SUP]F-FDG PET to quantitatively evaluate glucose metabolism using macroparametric quantification and assess specific glucose delivery and phosphorylation processes using microparametric quantification for studying recovery from coronavirus disease 2019 (COVID-19). Methods: The study included 13 healthy subjects and 12 recovering COVID-19 subjects within 8 wk of confirmed diagnosis. Each subject had a 1-h dynamic [SUP]18[/SUP]F-FDG scan on the uEXPLORER total-body PET/CT system. Semiquantitative SUV and the SUV ratio relative to blood (SUVR) were calculated for different organs to measure glucose utilization. Tracer kinetic modeling was performed to quantify the microparametric blood-to-tissue [SUP]18[/SUP]F-FDG delivery rate [Formula: see text] and the phosphorylation rate k [SUB]3[/SUB], as well as the macroparametric [SUP]18[/SUP]F-FDG net influx rate ([Formula: see text]). Statistical tests were performed to examine differences between healthy subjects and recovering COVID-19 subjects. The effect of COVID-19 vaccination was also investigated. Results: We detected no significant difference in lung SUV but significantly higher lung SUVR and [Formula: see text] in COVID-19 recovery, indicating improved sensitivity of kinetic quantification for detecting the difference in glucose metabolism. A significant difference was also observed in the lungs with the phosphorylation rate k [SUB]3[/SUB] but not with [Formula: see text], which suggests that glucose phosphorylation, rather than glucose delivery, drives the observed difference of glucose metabolism. Meanwhile, there was no or little difference in bone marrow [SUP]18[/SUP]F-FDG metabolism measured with SUV, SUVR, and [Formula: see text] but a significantly higher bone marrow [Formula: see text] in the COVID-19 group, suggesting a difference in glucose delivery. Vaccinated COVID-19 subjects had a lower lung [Formula: see text] and a higher spleen [Formula: see text] than unvaccinated COVID-19 subjects. Conclusion: Higher lung glucose metabolism and bone marrow glucose delivery were observed with total-body multiparametric [SUP]18[/SUP]F-FDG PET in recovering COVID-19 subjects than in healthy subjects, implying continued inflammation during recovery. Vaccination demonstrated potential protection effects. Total-body multiparametric PET of [SUP]18[/SUP]F-FDG can provide a more sensitive tool and more insights than conventional whole-body static [SUP]18[/SUP]F-FDG imaging to evaluate metabolic changes in systemic diseases such as COVID-19.
Keywords: 18F-FDG PET; COVID-19; total-body dynamic PET; tracer kinetic modeling.
. 2023 Aug 17;jnumed.123.265723.
doi: 10.2967/jnumed.123.265723. Online ahead of print. Total-Body Multiparametric PET Quantification of [SUP]18[/SUP]F-FDG Delivery and Metabolism in the Study of Coronavirus Disease 2019 Recovery
Yiran Wang[SUP] 1 2 [/SUP], Lorenzo Nardo[SUP] 3 [/SUP], Benjamin A Spencer[SUP] 3 2 [/SUP], Yasser G Abdelhafez[SUP] 3 4 [/SUP], Elizabeth J Li[SUP] 2 [/SUP], Negar Omidvari[SUP] 2 [/SUP], Abhijit J Chaudhari[SUP] 3 [/SUP], Ramsey D Badawi[SUP] 3 2 [/SUP], Terry Jones[SUP] 3 [/SUP], Simon R Cherry[SUP] 3 2 [/SUP], Guobao Wang[SUP] 3 [/SUP]
Affiliations
- PMID: 37591539
- DOI: 10.2967/jnumed.123.265723
Conventional whole-body static [SUP]18[/SUP]F-FDG PET imaging provides a semiquantitative evaluation of overall glucose metabolism without insight into the specific transport and metabolic steps. Here we demonstrate the ability of total-body multiparametric [SUP]18[/SUP]F-FDG PET to quantitatively evaluate glucose metabolism using macroparametric quantification and assess specific glucose delivery and phosphorylation processes using microparametric quantification for studying recovery from coronavirus disease 2019 (COVID-19). Methods: The study included 13 healthy subjects and 12 recovering COVID-19 subjects within 8 wk of confirmed diagnosis. Each subject had a 1-h dynamic [SUP]18[/SUP]F-FDG scan on the uEXPLORER total-body PET/CT system. Semiquantitative SUV and the SUV ratio relative to blood (SUVR) were calculated for different organs to measure glucose utilization. Tracer kinetic modeling was performed to quantify the microparametric blood-to-tissue [SUP]18[/SUP]F-FDG delivery rate [Formula: see text] and the phosphorylation rate k [SUB]3[/SUB], as well as the macroparametric [SUP]18[/SUP]F-FDG net influx rate ([Formula: see text]). Statistical tests were performed to examine differences between healthy subjects and recovering COVID-19 subjects. The effect of COVID-19 vaccination was also investigated. Results: We detected no significant difference in lung SUV but significantly higher lung SUVR and [Formula: see text] in COVID-19 recovery, indicating improved sensitivity of kinetic quantification for detecting the difference in glucose metabolism. A significant difference was also observed in the lungs with the phosphorylation rate k [SUB]3[/SUB] but not with [Formula: see text], which suggests that glucose phosphorylation, rather than glucose delivery, drives the observed difference of glucose metabolism. Meanwhile, there was no or little difference in bone marrow [SUP]18[/SUP]F-FDG metabolism measured with SUV, SUVR, and [Formula: see text] but a significantly higher bone marrow [Formula: see text] in the COVID-19 group, suggesting a difference in glucose delivery. Vaccinated COVID-19 subjects had a lower lung [Formula: see text] and a higher spleen [Formula: see text] than unvaccinated COVID-19 subjects. Conclusion: Higher lung glucose metabolism and bone marrow glucose delivery were observed with total-body multiparametric [SUP]18[/SUP]F-FDG PET in recovering COVID-19 subjects than in healthy subjects, implying continued inflammation during recovery. Vaccination demonstrated potential protection effects. Total-body multiparametric PET of [SUP]18[/SUP]F-FDG can provide a more sensitive tool and more insights than conventional whole-body static [SUP]18[/SUP]F-FDG imaging to evaluate metabolic changes in systemic diseases such as COVID-19.
Keywords: 18F-FDG PET; COVID-19; total-body dynamic PET; tracer kinetic modeling.