tetano
Editor, Senior Moderator
J Pediatr Hematol Oncol
. 2020 Sep 29.
doi: 10.1097/MPH.0000000000001961. Online ahead of print.
A Novel Use of Romiplostim for SARS-CoV-2-induced Thrombocytopenia
Coursen W Schneider[SUP] 1 [/SUP], Scott W Penney[SUP] 2 [/SUP], Alison M Helfrich[SUP] 3 [/SUP], Kip R Hartman[SUP] 2 [/SUP], Kenneth Lieuw[SUP] 2 [/SUP]
Affiliations
Abstract
The literature regarding coronavirus disease of 2019 (COVID-19) infection in pediatrics indicates that children have less severe clinical presentations and lower mortality rates. There remains limited data regarding hematologic sequelae in pediatric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Romiplostim has shown a platelet response in pediatric patients with chronic immune thrombocytopenic purpura, and eltrombopag is proven to increase platelet counts in patients with inherited thrombocytopenia. We review SARS-CoV-2-associated thrombocytopenia and present a pediatric patient with acute on chronic thrombocytopenia in the setting of COVID-19 with subsequent platelet recovery using romiplostim.
. 2020 Sep 29.
doi: 10.1097/MPH.0000000000001961. Online ahead of print.
A Novel Use of Romiplostim for SARS-CoV-2-induced Thrombocytopenia
Coursen W Schneider[SUP] 1 [/SUP], Scott W Penney[SUP] 2 [/SUP], Alison M Helfrich[SUP] 3 [/SUP], Kip R Hartman[SUP] 2 [/SUP], Kenneth Lieuw[SUP] 2 [/SUP]
Affiliations
- PMID: 33003146
- DOI: 10.1097/MPH.0000000000001961
Abstract
The literature regarding coronavirus disease of 2019 (COVID-19) infection in pediatrics indicates that children have less severe clinical presentations and lower mortality rates. There remains limited data regarding hematologic sequelae in pediatric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Romiplostim has shown a platelet response in pediatric patients with chronic immune thrombocytopenic purpura, and eltrombopag is proven to increase platelet counts in patients with inherited thrombocytopenia. We review SARS-CoV-2-associated thrombocytopenia and present a pediatric patient with acute on chronic thrombocytopenia in the setting of COVID-19 with subsequent platelet recovery using romiplostim.