tetano
Editor, Senior Moderator
J Pers Med
. 2021 Nov 29;11(12):1258.
doi: 10.3390/jpm11121258.
Comparison of Clinical Characteristics and Outcomes of Younger and Elderly Patients with Severe COVID-19 in Korea: A Retrospective Multicenter Study
Gil Myeong Seong[SUP] 1 [/SUP], Ae-Rin Baek[SUP] 2 [/SUP], Moon Seong Baek[SUP] 3 [/SUP], Won-Young Kim[SUP] 3 [/SUP], Jin Hyoung Kim[SUP] 4 [/SUP], Bo Young Lee[SUP] 5 [/SUP], Yong Sub Na[SUP] 6 [/SUP], Song-I Lee[SUP] 7 [/SUP]
Affiliations
Abstract
Old age is associated with disease severity and poor prognosis among coronavirus disease 2019 (COVID-19) cases; however, characteristics of elderly patients with severe COVID-19 are limited. We aimed to assess the clinical characteristics and outcomes of patients hospitalized with severe COVID-19 at tertiary care centers in South Korea. This retrospective multicenter study included patients with severe COVID-19 who were admitted at seven hospitals in South Korea from 2 February 2020 to 28 February 2021. The Cox regression analyses were performed to assess factors associated with the in-hospital mortality. Of 488 patients with severe COVID-19, 318 (65.2%) were elderly (≥65 years). The older patient group had more underlying diseases and a higher severity score than the younger patient group. The older patient group had a higher in-hospital mortality rate than the younger patient group (25.5% versus 4.7%, p-value < 0.001). The in-hospital mortality risk factors among patients with severe COVID-19 included age, acute physiology and chronic health evaluation II score, presence of diabetes and chronic obstructive lung disease, high white blood cell count, low neutrophil-lymphocyte ratio and platelet count, do-not-resuscitate order, and treatment with invasive mechanical ventilation. In addition to old age, disease severity and examination results must be considered in treatment decision-making.
. 2021 Nov 29;11(12):1258.
doi: 10.3390/jpm11121258.
Comparison of Clinical Characteristics and Outcomes of Younger and Elderly Patients with Severe COVID-19 in Korea: A Retrospective Multicenter Study
Gil Myeong Seong[SUP] 1 [/SUP], Ae-Rin Baek[SUP] 2 [/SUP], Moon Seong Baek[SUP] 3 [/SUP], Won-Young Kim[SUP] 3 [/SUP], Jin Hyoung Kim[SUP] 4 [/SUP], Bo Young Lee[SUP] 5 [/SUP], Yong Sub Na[SUP] 6 [/SUP], Song-I Lee[SUP] 7 [/SUP]
Affiliations
- PMID: 34945730
- DOI: 10.3390/jpm11121258
Abstract
Old age is associated with disease severity and poor prognosis among coronavirus disease 2019 (COVID-19) cases; however, characteristics of elderly patients with severe COVID-19 are limited. We aimed to assess the clinical characteristics and outcomes of patients hospitalized with severe COVID-19 at tertiary care centers in South Korea. This retrospective multicenter study included patients with severe COVID-19 who were admitted at seven hospitals in South Korea from 2 February 2020 to 28 February 2021. The Cox regression analyses were performed to assess factors associated with the in-hospital mortality. Of 488 patients with severe COVID-19, 318 (65.2%) were elderly (≥65 years). The older patient group had more underlying diseases and a higher severity score than the younger patient group. The older patient group had a higher in-hospital mortality rate than the younger patient group (25.5% versus 4.7%, p-value < 0.001). The in-hospital mortality risk factors among patients with severe COVID-19 included age, acute physiology and chronic health evaluation II score, presence of diabetes and chronic obstructive lung disease, high white blood cell count, low neutrophil-lymphocyte ratio and platelet count, do-not-resuscitate order, and treatment with invasive mechanical ventilation. In addition to old age, disease severity and examination results must be considered in treatment decision-making.