tetano
Editor, Senior Moderator
J Prev Med Public Health
. 2021 Nov;54(6):422-430.
doi: 10.3961/jpmph.21.432. Epub 2021 Oct 21.
Adverse Birth Outcomes Among Pregnant Women With and Without COVID-19: A Comparative Study From Bangladesh
Sumaya Binte Masud[SUP] 1 2 [/SUP], Faiza Zebeen[SUP] 1 2 [/SUP], Dil Ware Alam[SUP] 1 [/SUP], Mosharap Hossian[SUP] 3 [/SUP], Sanjana Zaman[SUP] 4 [/SUP], Rowshan Ara Begum[SUP] 1 [/SUP], Mohammad Hayatun Nabi[SUP] 2 [/SUP], Mohammad Delwer Hossain Hawlader[SUP] 2 [/SUP]
Affiliations
Abstract
Objectives: Pregnant women are especially vulnerable to respiratory infections such as coronavirus disease 2019 (COVID-19), but insufficient research has investigated pregnancy and its outcomes in women with COVID-19. This cross-sectional study compared birth outcomes related to COVID-19 between Bangladeshi pregnant women with and without COVID-19.
Methods: The study was conducted at 3 tertiary referral hospitals in Dhaka, Bangladesh, from March to August 2020. Pregnant women admitted for delivery at these hospitals with laboratory results (reverse-transcription polymerase chain reaction) were analyzed. Using convenience sampling, we included 70 COVID-19-positive and 140 COVID-19-negative pregnant women. Trained and experienced midwives conducted the interviews. Data were analyzed using the t-test, the chi-square test, and univariate and multivariable linear and logistic regression.
Results: Pregnant women with COVID-19 were more likely to give birth to a preterm baby (adjusted odds ratio [aOR], 2.15; 95% confidence interval [CI], 1.06 to 4.37) and undergo a cesarean section (aOR, 3.27; 95% CI, 1.51 to 7.07). There were no significant differences in birth weight, premature rupture of membranes, and the Apgar score at 1 minute or 5 minutes post-delivery between women with and without COVID-19. All the newborn babies who were born to COVID-19-positive women were COVID-19-negative.
Conclusions: Our study suggests that pregnant women with COVID-19 were more likely to give birth to a preterm baby and undergo a cesarean section. For this reason, physicians should be particularly cautious to minimize adverse birth outcomes among pregnant women with COVID-19 and their newborn babies.
Keywords: Bangladesh; COVID-19; Cesarean section; Communicable diseases; Pregnancy outcome; Preterm birth.
. 2021 Nov;54(6):422-430.
doi: 10.3961/jpmph.21.432. Epub 2021 Oct 21.
Adverse Birth Outcomes Among Pregnant Women With and Without COVID-19: A Comparative Study From Bangladesh
Sumaya Binte Masud[SUP] 1 2 [/SUP], Faiza Zebeen[SUP] 1 2 [/SUP], Dil Ware Alam[SUP] 1 [/SUP], Mosharap Hossian[SUP] 3 [/SUP], Sanjana Zaman[SUP] 4 [/SUP], Rowshan Ara Begum[SUP] 1 [/SUP], Mohammad Hayatun Nabi[SUP] 2 [/SUP], Mohammad Delwer Hossain Hawlader[SUP] 2 [/SUP]
Affiliations
- PMID: 34875825
- DOI: 10.3961/jpmph.21.432
Abstract
Objectives: Pregnant women are especially vulnerable to respiratory infections such as coronavirus disease 2019 (COVID-19), but insufficient research has investigated pregnancy and its outcomes in women with COVID-19. This cross-sectional study compared birth outcomes related to COVID-19 between Bangladeshi pregnant women with and without COVID-19.
Methods: The study was conducted at 3 tertiary referral hospitals in Dhaka, Bangladesh, from March to August 2020. Pregnant women admitted for delivery at these hospitals with laboratory results (reverse-transcription polymerase chain reaction) were analyzed. Using convenience sampling, we included 70 COVID-19-positive and 140 COVID-19-negative pregnant women. Trained and experienced midwives conducted the interviews. Data were analyzed using the t-test, the chi-square test, and univariate and multivariable linear and logistic regression.
Results: Pregnant women with COVID-19 were more likely to give birth to a preterm baby (adjusted odds ratio [aOR], 2.15; 95% confidence interval [CI], 1.06 to 4.37) and undergo a cesarean section (aOR, 3.27; 95% CI, 1.51 to 7.07). There were no significant differences in birth weight, premature rupture of membranes, and the Apgar score at 1 minute or 5 minutes post-delivery between women with and without COVID-19. All the newborn babies who were born to COVID-19-positive women were COVID-19-negative.
Conclusions: Our study suggests that pregnant women with COVID-19 were more likely to give birth to a preterm baby and undergo a cesarean section. For this reason, physicians should be particularly cautious to minimize adverse birth outcomes among pregnant women with COVID-19 and their newborn babies.
Keywords: Bangladesh; COVID-19; Cesarean section; Communicable diseases; Pregnancy outcome; Preterm birth.