tetano
Editor, Senior Moderator
J Surg Oncol
. 2021 Jun 6.
doi: 10.1002/jso.26561. Online ahead of print.
A review of nasopharyngeal swab and saliva tests for SARS-CoV-2 infection: Disease timelines, relative sensitivities, and test optimization
Marylin Roque[SUP] 1 [/SUP], Kevin Proudfoot[SUP] 1 [/SUP], Vadim Mathys[SUP] 1 [/SUP], Sophie Yu[SUP] 1 [/SUP], Natalie Krieger[SUP] 1 [/SUP], Thomas Gernon[SUP] 2 [/SUP], Kash Gokli[SUP] 1 [/SUP], Stanley Hamilton[SUP] 3 [/SUP], Colin Cook[SUP] 2 [/SUP], Yuman Fong[SUP] 2 [/SUP]
Affiliations
Abstract
Testing is an essential part of containment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This review summarizes studies for SARS-CoV-2 infection and testing. Nasopharyngeal samples are best at sensitivity detection, especially in early stages of disease and in asymptomatic individuals. Current swab processing involves a 100- to 1000-fold dilution of the patient sample. Future optimization of testing should focus on using smaller volumes of viral transport media and swab designs to increase comfort and increased viral adhesion.
Keywords: COVID-19; bronchitis; pharyngitis; pneumonia; respiratory infection.
. 2021 Jun 6.
doi: 10.1002/jso.26561. Online ahead of print.
A review of nasopharyngeal swab and saliva tests for SARS-CoV-2 infection: Disease timelines, relative sensitivities, and test optimization
Marylin Roque[SUP] 1 [/SUP], Kevin Proudfoot[SUP] 1 [/SUP], Vadim Mathys[SUP] 1 [/SUP], Sophie Yu[SUP] 1 [/SUP], Natalie Krieger[SUP] 1 [/SUP], Thomas Gernon[SUP] 2 [/SUP], Kash Gokli[SUP] 1 [/SUP], Stanley Hamilton[SUP] 3 [/SUP], Colin Cook[SUP] 2 [/SUP], Yuman Fong[SUP] 2 [/SUP]
Affiliations
- PMID: 34091905
- DOI: 10.1002/jso.26561
Abstract
Testing is an essential part of containment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This review summarizes studies for SARS-CoV-2 infection and testing. Nasopharyngeal samples are best at sensitivity detection, especially in early stages of disease and in asymptomatic individuals. Current swab processing involves a 100- to 1000-fold dilution of the patient sample. Future optimization of testing should focus on using smaller volumes of viral transport media and swab designs to increase comfort and increased viral adhesion.
Keywords: COVID-19; bronchitis; pharyngitis; pneumonia; respiratory infection.