tetano
Editor, Senior Moderator
J Transl Med
. 2021 Dec 24;19(1):528.
doi: 10.1186/s12967-021-03198-2.
Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study
Yi Wang[SUP] #[/SUP][SUP] 1 [/SUP], Hui Deng[SUP] #[/SUP][SUP] 1 [/SUP], Yihuai Pan[SUP] 1 [/SUP], Lijian Jin[SUP] 2 [/SUP], Rongdang Hu[SUP] 1 [/SUP], Yongyong Lu[SUP] 3 [/SUP], Wenhai Deng[SUP] 4 [/SUP], Weijian Sun[SUP] 5 [/SUP], Chengshui Chen[SUP] 6 7 [/SUP], Xian Shen[SUP] 8 [/SUP], Xiu-Feng Huang[SUP] 9 10 [/SUP]
Affiliations
Abstract
Background: Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity.
Methods: Summary statistics of COVID-19 susceptibility and severity were retrieved from the COVID-19 Host Genetics Initiative and used as outcomes. Single nucleotide polymorphisms associated with PD in Genome-wide association study were included as exposure. Inverse-variance weighted (IVW) method was employed as the main approach to analyze the causal relationships between PD and COVID-19. Three additional methods were adopted, allowing the existence of horizontal pleiotropy, including MR-Egger regression, weighted median and weighted mode methods. Comprehensive sensitivity analyses were also conducted for estimating the robustness of the identified associations.
Results: The MR estimates showed that PD was significantly associated with significantly higher susceptibility to COVID-19 using IVW (OR = 1.024, P = 0.017, 95% CI 1.004-1.045) and weighted median method (OR = 1.029, P = 0.024, 95% CI 1.003-1.055). Furthermore, it revealed that PD was significantly linked to COVID-19 severity based on the comparison of hospitalization versus population controls (IVW, OR = 1.025, P = 0.039, 95% CI 1.001-1.049; weighted median, OR = 1.030, P = 0.027, 95% CI 1.003-1.058). No such association was observed in the cohort of highly severe cases confirmed versus those not hospitalized due to COVID-19.
Conclusions: We provide evidence on the possible causality of PD accounting for the susceptibility and severity of COVID-19, highlighting the importance of oral/periodontal healthcare for general wellbeing during the pandemic and beyond.
Keywords: COVID-19; Mendelian randomization; Periodontal disease; Risk factor.
. 2021 Dec 24;19(1):528.
doi: 10.1186/s12967-021-03198-2.
Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study
Yi Wang[SUP] #[/SUP][SUP] 1 [/SUP], Hui Deng[SUP] #[/SUP][SUP] 1 [/SUP], Yihuai Pan[SUP] 1 [/SUP], Lijian Jin[SUP] 2 [/SUP], Rongdang Hu[SUP] 1 [/SUP], Yongyong Lu[SUP] 3 [/SUP], Wenhai Deng[SUP] 4 [/SUP], Weijian Sun[SUP] 5 [/SUP], Chengshui Chen[SUP] 6 7 [/SUP], Xian Shen[SUP] 8 [/SUP], Xiu-Feng Huang[SUP] 9 10 [/SUP]
Affiliations
- PMID: 34952598
- DOI: 10.1186/s12967-021-03198-2
Abstract
Background: Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity.
Methods: Summary statistics of COVID-19 susceptibility and severity were retrieved from the COVID-19 Host Genetics Initiative and used as outcomes. Single nucleotide polymorphisms associated with PD in Genome-wide association study were included as exposure. Inverse-variance weighted (IVW) method was employed as the main approach to analyze the causal relationships between PD and COVID-19. Three additional methods were adopted, allowing the existence of horizontal pleiotropy, including MR-Egger regression, weighted median and weighted mode methods. Comprehensive sensitivity analyses were also conducted for estimating the robustness of the identified associations.
Results: The MR estimates showed that PD was significantly associated with significantly higher susceptibility to COVID-19 using IVW (OR = 1.024, P = 0.017, 95% CI 1.004-1.045) and weighted median method (OR = 1.029, P = 0.024, 95% CI 1.003-1.055). Furthermore, it revealed that PD was significantly linked to COVID-19 severity based on the comparison of hospitalization versus population controls (IVW, OR = 1.025, P = 0.039, 95% CI 1.001-1.049; weighted median, OR = 1.030, P = 0.027, 95% CI 1.003-1.058). No such association was observed in the cohort of highly severe cases confirmed versus those not hospitalized due to COVID-19.
Conclusions: We provide evidence on the possible causality of PD accounting for the susceptibility and severity of COVID-19, highlighting the importance of oral/periodontal healthcare for general wellbeing during the pandemic and beyond.
Keywords: COVID-19; Mendelian randomization; Periodontal disease; Risk factor.