tetano
Editor, Senior Moderator
J Trop Pediatr
. 2021 Nov 8;fmab094.
doi: 10.1093/tropej/fmab094. Online ahead of print.
Impact of COVID-19 infection on neonatal birth outcomes
Maryam Vizheh[SUP] 1 [/SUP], Maryam Allahdadian[SUP] 2 [/SUP], Salut Muhidin[SUP] 3 [/SUP], Mahboubeh Valiani[SUP] 4 [/SUP], Khadijeh Bagheri[SUP] 5 [/SUP], Forogh Borandegi[SUP] 6 [/SUP], Golnaz Ghasimi[SUP] 7 [/SUP]
Affiliations
Abstract
Introduction: There is limited data on newborns born to mothers with COVID-19 infection. This multicenter cohort study aimed to investigate the clinical characteristics and outcomes of neonates born to mothers with and without COVID-19 infection to fill a gap in the literature review.
Methods: The medical records of all neonates in Isfahan, Iran, between October 2020 and March 2021, were retrospectively reviewed.
Results: Among the 600 neonates in this study, 255 (42.5%) were in the infected group, and 345 (57.5%) were assigned to the control group as they were born to non-infected mothers. In the infected group, sepsis, fever, and pneumothorax were detected in 3 (1.2%), 3 (1.2%), and 4 (1.6%) neonates, respectively, compared to no case in the control group. In the infected group, Neonatal respiratory distress (NRDS) (32, 12.5%) was significantly higher than the control group (27, 10.6%). Asphyxia in the infected group was 22(6.4%), compared to 19 (5.5%), in the control group. Preterm labor (PTL) (55, 21.65%), premature rupture of membranes (PROM) (24, 9.4%) and intra-uterine growth retardation (IUGR) (15, 5.9%) were significantly higher in women with COVID-19 (45, 13.0%, 4, 1.2%, and 7, 2.0%, respectively). Low birth weight (LBW) accounted for 42 (16.5%) neonates in the infected group and 25 (7.2%) in the control group (p < 0.05). Of the 255 neonates born to infected mothers, 38 (14.9%) were admitted to the Neonatal Intensive Care Unit (NICU), compared to 31 out of 345 (9.0%) in the control group (p < 0.05). RT-PCR test results were positive in two newborns (0.8%), one of whom died of Necrotizing enterocolitis.
Conclusion: As a result of maternal COVID-19 infections, neonates experienced higher rates of sepsis, fever, pneumothorax, asphyxia, and NRDS in addition to PTL, PROM, IUGR, and LBW.
Lay summary: Contradictory results have been reported on the impact of COVID-19 infection on neonatal outcomes. We conducted a review of 600 cases of neonates, with 255 (42.5%) in the COVID-19 infected and 345 (57.5%) in the control group. The results indicated that neonates born to women with COVID-19 showed higher rates of sepsis, fever, pneumothorax, asphyxia, and neonatal respiratory distress in addition to preterm labor, premature rupture of membranes, intra-uterin growth retardation, and low birth weight.
Keywords: 2019 novel coronavirus; COVID-19; neonates; outcomes; pregnancy; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2021 Nov 8;fmab094.
doi: 10.1093/tropej/fmab094. Online ahead of print.
Impact of COVID-19 infection on neonatal birth outcomes
Maryam Vizheh[SUP] 1 [/SUP], Maryam Allahdadian[SUP] 2 [/SUP], Salut Muhidin[SUP] 3 [/SUP], Mahboubeh Valiani[SUP] 4 [/SUP], Khadijeh Bagheri[SUP] 5 [/SUP], Forogh Borandegi[SUP] 6 [/SUP], Golnaz Ghasimi[SUP] 7 [/SUP]
Affiliations
- PMID: 34748020
- DOI: 10.1093/tropej/fmab094
Abstract
Introduction: There is limited data on newborns born to mothers with COVID-19 infection. This multicenter cohort study aimed to investigate the clinical characteristics and outcomes of neonates born to mothers with and without COVID-19 infection to fill a gap in the literature review.
Methods: The medical records of all neonates in Isfahan, Iran, between October 2020 and March 2021, were retrospectively reviewed.
Results: Among the 600 neonates in this study, 255 (42.5%) were in the infected group, and 345 (57.5%) were assigned to the control group as they were born to non-infected mothers. In the infected group, sepsis, fever, and pneumothorax were detected in 3 (1.2%), 3 (1.2%), and 4 (1.6%) neonates, respectively, compared to no case in the control group. In the infected group, Neonatal respiratory distress (NRDS) (32, 12.5%) was significantly higher than the control group (27, 10.6%). Asphyxia in the infected group was 22(6.4%), compared to 19 (5.5%), in the control group. Preterm labor (PTL) (55, 21.65%), premature rupture of membranes (PROM) (24, 9.4%) and intra-uterine growth retardation (IUGR) (15, 5.9%) were significantly higher in women with COVID-19 (45, 13.0%, 4, 1.2%, and 7, 2.0%, respectively). Low birth weight (LBW) accounted for 42 (16.5%) neonates in the infected group and 25 (7.2%) in the control group (p < 0.05). Of the 255 neonates born to infected mothers, 38 (14.9%) were admitted to the Neonatal Intensive Care Unit (NICU), compared to 31 out of 345 (9.0%) in the control group (p < 0.05). RT-PCR test results were positive in two newborns (0.8%), one of whom died of Necrotizing enterocolitis.
Conclusion: As a result of maternal COVID-19 infections, neonates experienced higher rates of sepsis, fever, pneumothorax, asphyxia, and NRDS in addition to PTL, PROM, IUGR, and LBW.
Lay summary: Contradictory results have been reported on the impact of COVID-19 infection on neonatal outcomes. We conducted a review of 600 cases of neonates, with 255 (42.5%) in the COVID-19 infected and 345 (57.5%) in the control group. The results indicated that neonates born to women with COVID-19 showed higher rates of sepsis, fever, pneumothorax, asphyxia, and neonatal respiratory distress in addition to preterm labor, premature rupture of membranes, intra-uterin growth retardation, and low birth weight.
Keywords: 2019 novel coronavirus; COVID-19; neonates; outcomes; pregnancy; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).