tetano
Editor, Senior Moderator
J Trop Pediatr
. 2021 Jul 12;fmab062.
doi: 10.1093/tropej/fmab062. Online ahead of print.
Neurological manifestations of paediatric acute COVID infections: A single centre experience
Beril Dilber[SUP] 1 [/SUP], Zeynep Gökçe Gayretli Aydın[SUP] 2 [/SUP], Osman Yeşilbaş[SUP] 3 [/SUP], Elif Sağ[SUP] 4 [/SUP], Nurdan Kaykı Aksoy[SUP] 5 [/SUP], Fırat Gündoğmuş[SUP] 5 [/SUP], Burcu Parıltan Küçükalioğlu[SUP] 5 [/SUP], Semra Atasoy Yılmaz[SUP] 5 [/SUP], Yeşeren Nil Demirhan[SUP] 5 [/SUP], Nurşen Çelik[SUP] 5 [/SUP], Abdullah Karaca[SUP] 5 [/SUP], Neşe Yalçın Ertem[SUP] 5 [/SUP], Ramazan Özdemir[SUP] 5 [/SUP], Halil İbrahim Aksoy[SUP] 5 [/SUP], Emine Esra Öztürk[SUP] 5 [/SUP], Berna Saygın[SUP] 6 [/SUP], Filiz Aktürk Acar[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, while serious complications may occur in conjunction with both acute infection and neurological symptoms, which have been predominantly reported in adults. The neurological complications in these patients vary based on patient age and underlying comorbidities. Data on clinical features, particularly neurological features, and prognostic factors in children and adolescents are limited. The present study provides a concise overview of neurological complications in pediatric COVID-19 cases.
Materials and methods: The retrospective study reviewed medical records of all patients who were admitted to our hospital and were diagnosed with COVID-19 by real-time reverse-transcription polymerase-chain-reaction (RT-PCR) assay between March 11, 2020 and January 30, 2021. Patients with a positive PCR result were categorized into two groups: Out Patient Departments (OPD) patients and In Patient Departments (IPD).
Results: Of the 2,530 children who underwent RT-PCR during the study period, 382 (8.6%) were confirmed as COVID-19 positive, comprising 188 (49.2%) girls and 194 (50.8%) boys with a mean age of 7.14±5.84 (range, 0-17) years. Neurological complications that required hospitalization were present in 34 (8.9%) patients, including seizure (52.9%), headache (38.2%), dizziness (11.1%) and meningoencephalitis (%5.8).
Conclusion: The results indicated that neurological manifestations are not rare in children suffering from COVID-19. Seizures, headaches, dizziness, anosmia, ageusia, and meningoencephalitis major neurological manifestations during acute COVID-19 disease. Although seizures were the most common cause of hospitalization in IPD patients, the frequency of meningoensalitis was quite high. Seizures were observed as febrile seizures for children under six years of age and afebrile seizures for those over 6 years of age. Febrile seizure accounted for half of all seizure children.
Keywords: COVID-19; adolescence; infant; neonates; neurological manifestations.
. 2021 Jul 12;fmab062.
doi: 10.1093/tropej/fmab062. Online ahead of print.
Neurological manifestations of paediatric acute COVID infections: A single centre experience
Beril Dilber[SUP] 1 [/SUP], Zeynep Gökçe Gayretli Aydın[SUP] 2 [/SUP], Osman Yeşilbaş[SUP] 3 [/SUP], Elif Sağ[SUP] 4 [/SUP], Nurdan Kaykı Aksoy[SUP] 5 [/SUP], Fırat Gündoğmuş[SUP] 5 [/SUP], Burcu Parıltan Küçükalioğlu[SUP] 5 [/SUP], Semra Atasoy Yılmaz[SUP] 5 [/SUP], Yeşeren Nil Demirhan[SUP] 5 [/SUP], Nurşen Çelik[SUP] 5 [/SUP], Abdullah Karaca[SUP] 5 [/SUP], Neşe Yalçın Ertem[SUP] 5 [/SUP], Ramazan Özdemir[SUP] 5 [/SUP], Halil İbrahim Aksoy[SUP] 5 [/SUP], Emine Esra Öztürk[SUP] 5 [/SUP], Berna Saygın[SUP] 6 [/SUP], Filiz Aktürk Acar[SUP] 6 [/SUP]
Affiliations
- PMID: 34254129
- DOI: 10.1093/tropej/fmab062
Abstract
Background: Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, while serious complications may occur in conjunction with both acute infection and neurological symptoms, which have been predominantly reported in adults. The neurological complications in these patients vary based on patient age and underlying comorbidities. Data on clinical features, particularly neurological features, and prognostic factors in children and adolescents are limited. The present study provides a concise overview of neurological complications in pediatric COVID-19 cases.
Materials and methods: The retrospective study reviewed medical records of all patients who were admitted to our hospital and were diagnosed with COVID-19 by real-time reverse-transcription polymerase-chain-reaction (RT-PCR) assay between March 11, 2020 and January 30, 2021. Patients with a positive PCR result were categorized into two groups: Out Patient Departments (OPD) patients and In Patient Departments (IPD).
Results: Of the 2,530 children who underwent RT-PCR during the study period, 382 (8.6%) were confirmed as COVID-19 positive, comprising 188 (49.2%) girls and 194 (50.8%) boys with a mean age of 7.14±5.84 (range, 0-17) years. Neurological complications that required hospitalization were present in 34 (8.9%) patients, including seizure (52.9%), headache (38.2%), dizziness (11.1%) and meningoencephalitis (%5.8).
Conclusion: The results indicated that neurological manifestations are not rare in children suffering from COVID-19. Seizures, headaches, dizziness, anosmia, ageusia, and meningoencephalitis major neurological manifestations during acute COVID-19 disease. Although seizures were the most common cause of hospitalization in IPD patients, the frequency of meningoensalitis was quite high. Seizures were observed as febrile seizures for children under six years of age and afebrile seizures for those over 6 years of age. Febrile seizure accounted for half of all seizure children.
Keywords: COVID-19; adolescence; infant; neonates; neurological manifestations.