tetano
Editor, Senior Moderator
J Vet Med Sci
. 2020 Aug 5.
doi: 10.1292/jvms.20-0313. Online ahead of print.
Role of cytotoxic T lymphocytes and interferon-γ in coronavirus infection: lessons from murine coronavirus infections in mice
Shigeru Kyuwa[SUP] 1 [/SUP], Yuki Sugiura[SUP] 1 [/SUP]
Affiliations
Abstract
Murine coronavirus (CoV) is a beta-CoV that infects mice by binding to carcinoembryonic antigen-related cell adhesion molecule 1. Intraperitoneal infection with the murine CoV strain JHM (JHMV) induces acute mild hepatitis in mice. While both innate and acquired immune responses play a significant role in the protection against murine CoV infection in mice, CD8[SUP]+[/SUP] cytotoxic T lymphocytes (CTLs) and interferon-γ are essential for viral clearance in JHMV-induced hepatitis. In addition, CoVs are characterized by high diversity, caused by mutations, recombination, and gene gain/loss. 25V16G is an immune-escape JHMV variant, which lacks a dominant CTL epitope. By evading immune responses, 25V16G establishes persistent infections, leading to granulomatous serositis in interferon-γ-deficient mice. These examples of CoV-associated pathogenesis in mice might provide useful information on other CoV infections, including coronavirus disease 2019 (COVID-19).
Keywords: animal model; coronavirus; cytotoxic T lymphocyte; interferon-γ.
. 2020 Aug 5.
doi: 10.1292/jvms.20-0313. Online ahead of print.
Role of cytotoxic T lymphocytes and interferon-γ in coronavirus infection: lessons from murine coronavirus infections in mice
Shigeru Kyuwa[SUP] 1 [/SUP], Yuki Sugiura[SUP] 1 [/SUP]
Affiliations
- PMID: 32759577
- DOI: 10.1292/jvms.20-0313
Abstract
Murine coronavirus (CoV) is a beta-CoV that infects mice by binding to carcinoembryonic antigen-related cell adhesion molecule 1. Intraperitoneal infection with the murine CoV strain JHM (JHMV) induces acute mild hepatitis in mice. While both innate and acquired immune responses play a significant role in the protection against murine CoV infection in mice, CD8[SUP]+[/SUP] cytotoxic T lymphocytes (CTLs) and interferon-γ are essential for viral clearance in JHMV-induced hepatitis. In addition, CoVs are characterized by high diversity, caused by mutations, recombination, and gene gain/loss. 25V16G is an immune-escape JHMV variant, which lacks a dominant CTL epitope. By evading immune responses, 25V16G establishes persistent infections, leading to granulomatous serositis in interferon-γ-deficient mice. These examples of CoV-associated pathogenesis in mice might provide useful information on other CoV infections, including coronavirus disease 2019 (COVID-19).
Keywords: animal model; coronavirus; cytotoxic T lymphocyte; interferon-γ.