Giuseppe
Emeritus
Interleukin-15 is critical in the pathogenesis of influenza A virus-induced acute lung injury. (J Virol., abstract, edited)
[Source: US National Library of Medicine, (LINK). Edited.]
J Virol. 2010 Mar 24. [Epub ahead of print]
Interleukin-15 is critical in the pathogenesis of influenza A virus-induced acute lung injury.
Nakamura R, Maeda N, Shibata K, Yamada H, Kase T, Yoshikai Y. - Division of Host Defense, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; Division of Bioinformatics, Digital Medicine Initiative, Kyushu University, Fukuoka, Japan; Osaka Prefectural Institute of Public Health, Osaka, Japan.
Highly pathogenic influenza A viruses cause acute severe pneumonia, to which the occurrence of "cytokine storm" has been proposed to contribute. Here we show that interleukin (IL)-15 knock out (KO) mice exhibited reduced mortality after infection with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) albeit no difference in the viral titer from control mice. There were significantly fewer antigen-specific CD44(+)CD8(+) T cells in the lungs of infected IL-15KO mice and adoptive transfer of the CD8(+) T cells deteriorated the survival of IL-15KO mice following influenza infection. Mice deficient in beta2-microglobulin by gene targeting and those depleted of CD8(+) T cells by in vivo administration of anti-CD8 monoclonal antibody displayed a reduced mortality rate after infection. These results indicate that IL-15-dependent CD8(+) T cells are at least partly responsible for the pathogenesis of acute pneumonia caused by influenza A virus.
PMID: 20335267 [PubMed - as supplied by publisher]
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[Source: US National Library of Medicine, (LINK). Edited.]
J Virol. 2010 Mar 24. [Epub ahead of print]
Interleukin-15 is critical in the pathogenesis of influenza A virus-induced acute lung injury.
Nakamura R, Maeda N, Shibata K, Yamada H, Kase T, Yoshikai Y. - Division of Host Defense, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; Division of Bioinformatics, Digital Medicine Initiative, Kyushu University, Fukuoka, Japan; Osaka Prefectural Institute of Public Health, Osaka, Japan.
Highly pathogenic influenza A viruses cause acute severe pneumonia, to which the occurrence of "cytokine storm" has been proposed to contribute. Here we show that interleukin (IL)-15 knock out (KO) mice exhibited reduced mortality after infection with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) albeit no difference in the viral titer from control mice. There were significantly fewer antigen-specific CD44(+)CD8(+) T cells in the lungs of infected IL-15KO mice and adoptive transfer of the CD8(+) T cells deteriorated the survival of IL-15KO mice following influenza infection. Mice deficient in beta2-microglobulin by gene targeting and those depleted of CD8(+) T cells by in vivo administration of anti-CD8 monoclonal antibody displayed a reduced mortality rate after infection. These results indicate that IL-15-dependent CD8(+) T cells are at least partly responsible for the pathogenesis of acute pneumonia caused by influenza A virus.
PMID: 20335267 [PubMed - as supplied by publisher]
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