tetano
Editor, Senior Moderator
J Zhejiang Univ Sci B
. 2020 Dec.;21(12):940-947.
doi: 10.1631/jzus.B2000304.
Factors associated with a SARS-CoV-2 recurrence after hospital discharge among patients with COVID-19: systematic review and meta-analysis
Meng-Qi Yao[SUP] 1 [/SUP], Qiu-Xian Zheng[SUP] 2 [/SUP], Jia Xu[SUP] 2 [/SUP], Jing-Wen Deng[SUP] 2 [/SUP], Tian-Tian Ge[SUP] 2 [/SUP], Hai-Bo Zhou[SUP] 2 [/SUP], Feng-Tian Wu[SUP] 2 [/SUP], Xin-Yu Gu[SUP] 2 [/SUP], Qin Yang[SUP] 2 [/SUP], Yan-Li Ren[SUP] 2 [/SUP], Gang Wang[SUP] 2 [/SUP], Zhi Chen[SUP] 2 [/SUP]
Affiliations
Abstract
Background: The proportion of recurrences after discharge among patients with coronavirus disease 2019 (COVID-19) was reported to be between 9.1% and 31.0%. Little is known about this issue, however, so we performed a meta-analysis to summarize the demographical, clinical, and laboratorial characteristics of non-recurrence and recurrence groups.
Methods: Comprehensive searches were conducted using eight electronic databases. Data regarding the demographic, clinical, and laboratorial characteristics of both recurrence and non-recurrence groups were extracted, and quantitative and qualitative analyses were conducted.
Results: Ten studies involving 2071 COVID-19 cases were included in this analysis. The proportion of recurrence cases involving patients with COVID-19 was 17.65% (between 12.38% and 25.16%) while older patients were more likely to experience recurrence (weighted mean difference (WMD)=1.67, range between 0.08 and 3.26). The time from discharge to recurrence was 13.38 d (between 12.08 and 14.69 d). Patients were categorized as having moderate severity (odds ratio (OR)=2.69, range between 1.30 and 5.58), while those with clinical symptoms including cough (OR=5.52, range between 3.18 and 9.60), sputum production (OR=5.10, range between 2.60 and 9.97), headache (OR=3.57, range between 1.36 and 9.35), and dizziness (OR=3.17, range between 1.12 and 8.96) were more likely to be associated with recurrence. Patients presenting with bilateral pulmonary infiltration and decreased leucocyte, platelet, and CD4[SUP]+[/SUP] T counts were at risk of COVID-19 recurrence (OR=1.71, range between 1.07 and 2.75; WMD=-1.06, range between -1.55 and -0.57, WMD=-40.39, range between -80.20 and -0.48, and WMD=-55.26, range between -105.92 and -4.60, respectively).
Conclusions: The main factors associated with the recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after hospital discharge were older age, moderate severity, bilateral pulmonary infiltration, laboratory findings including decreased leucocytes, platelets, and CD4[SUP]+[/SUP] T counts, and clinical symptoms including cough, sputum production, headache, and dizziness. These factors can be considered warning indicators for the recurrence of SARS-CoV-2 and might help the development of specific management strategies.
Keywords: Recurrence case; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Risk factor; Meta-analysis.
. 2020 Dec.;21(12):940-947.
doi: 10.1631/jzus.B2000304.
Factors associated with a SARS-CoV-2 recurrence after hospital discharge among patients with COVID-19: systematic review and meta-analysis
Meng-Qi Yao[SUP] 1 [/SUP], Qiu-Xian Zheng[SUP] 2 [/SUP], Jia Xu[SUP] 2 [/SUP], Jing-Wen Deng[SUP] 2 [/SUP], Tian-Tian Ge[SUP] 2 [/SUP], Hai-Bo Zhou[SUP] 2 [/SUP], Feng-Tian Wu[SUP] 2 [/SUP], Xin-Yu Gu[SUP] 2 [/SUP], Qin Yang[SUP] 2 [/SUP], Yan-Li Ren[SUP] 2 [/SUP], Gang Wang[SUP] 2 [/SUP], Zhi Chen[SUP] 2 [/SUP]
Affiliations
- PMID: 33843159
- DOI: 10.1631/jzus.B2000304
Abstract
Background: The proportion of recurrences after discharge among patients with coronavirus disease 2019 (COVID-19) was reported to be between 9.1% and 31.0%. Little is known about this issue, however, so we performed a meta-analysis to summarize the demographical, clinical, and laboratorial characteristics of non-recurrence and recurrence groups.
Methods: Comprehensive searches were conducted using eight electronic databases. Data regarding the demographic, clinical, and laboratorial characteristics of both recurrence and non-recurrence groups were extracted, and quantitative and qualitative analyses were conducted.
Results: Ten studies involving 2071 COVID-19 cases were included in this analysis. The proportion of recurrence cases involving patients with COVID-19 was 17.65% (between 12.38% and 25.16%) while older patients were more likely to experience recurrence (weighted mean difference (WMD)=1.67, range between 0.08 and 3.26). The time from discharge to recurrence was 13.38 d (between 12.08 and 14.69 d). Patients were categorized as having moderate severity (odds ratio (OR)=2.69, range between 1.30 and 5.58), while those with clinical symptoms including cough (OR=5.52, range between 3.18 and 9.60), sputum production (OR=5.10, range between 2.60 and 9.97), headache (OR=3.57, range between 1.36 and 9.35), and dizziness (OR=3.17, range between 1.12 and 8.96) were more likely to be associated with recurrence. Patients presenting with bilateral pulmonary infiltration and decreased leucocyte, platelet, and CD4[SUP]+[/SUP] T counts were at risk of COVID-19 recurrence (OR=1.71, range between 1.07 and 2.75; WMD=-1.06, range between -1.55 and -0.57, WMD=-40.39, range between -80.20 and -0.48, and WMD=-55.26, range between -105.92 and -4.60, respectively).
Conclusions: The main factors associated with the recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after hospital discharge were older age, moderate severity, bilateral pulmonary infiltration, laboratory findings including decreased leucocytes, platelets, and CD4[SUP]+[/SUP] T counts, and clinical symptoms including cough, sputum production, headache, and dizziness. These factors can be considered warning indicators for the recurrence of SARS-CoV-2 and might help the development of specific management strategies.
Keywords: Recurrence case; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Risk factor; Meta-analysis.