tetano
Editor, Senior Moderator
JACC Basic Transl Sci. 2020 Apr 10. doi: 10.1016/j.jacbts.2020.04.002. [Epub ahead of print]
COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies.
Atri D[SUP]1[/SUP], Siddiqi HK[SUP]1[/SUP], Lang J[SUP]1[/SUP], Nauffal V[SUP]1[/SUP], Morrow DA[SUP]1[/SUP], Bohula EA[SUP]1[/SUP].
Author information
Abstract
The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
? 2020 Published by Elsevier on behalf of the American College of Cardiology Foundation.
KEYWORDS:
ACE2, angiotensin-converting enzyme 2; ARDS, acute respiratory distress syndrome; CDC, Centers for Disease Control; CFR, case fatality rate; COVID-19; COVID-19, coronavirus disease-2019; Cardiovascular; CoV, coronavirus; DIC, disseminated intravascular coagulation; ER, endoplasmic reticulum; ICU, intensive care unit; SARS-CoV1 or 2, severe acute respiratory syndrome coronavirus-1 or -2; SARS-CoV2; SOFA, sequential organ failure assessment; TMPSS2, trasmembrane serine protease-2; Treatments; Virology; hsCRP, high sensitivity c-reactive protein
PMID:32292848PMCID:PMC7151394DOI:10.1016/j.jacbts.2020.04.002
Free PMC Article
COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies.
Atri D[SUP]1[/SUP], Siddiqi HK[SUP]1[/SUP], Lang J[SUP]1[/SUP], Nauffal V[SUP]1[/SUP], Morrow DA[SUP]1[/SUP], Bohula EA[SUP]1[/SUP].
Author information
Abstract
The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
? 2020 Published by Elsevier on behalf of the American College of Cardiology Foundation.
KEYWORDS:
ACE2, angiotensin-converting enzyme 2; ARDS, acute respiratory distress syndrome; CDC, Centers for Disease Control; CFR, case fatality rate; COVID-19; COVID-19, coronavirus disease-2019; Cardiovascular; CoV, coronavirus; DIC, disseminated intravascular coagulation; ER, endoplasmic reticulum; ICU, intensive care unit; SARS-CoV1 or 2, severe acute respiratory syndrome coronavirus-1 or -2; SARS-CoV2; SOFA, sequential organ failure assessment; TMPSS2, trasmembrane serine protease-2; Treatments; Virology; hsCRP, high sensitivity c-reactive protein
PMID:32292848PMCID:PMC7151394DOI:10.1016/j.jacbts.2020.04.002
Free PMC Article