sharon sanders
Editor-in-Chief & President
Original Investigation
Public Health
February 4, 2022
Prevalence of Select New Symptoms and Conditions Among Persons Aged Younger Than 20 Years and 20 Years or Older at 31 to 150 Days After Testing Positive or Negative for SARS-CoV-2
Alfonso C. Hernandez-Romieu, MD, MPH[SUP]1,2[/SUP]; Thomas W. Carton, PhD, MS[SUP]3[/SUP]; Sharon Saydah, PhD[SUP]2[/SUP]; et alEduardo Azziz-Baumgartner, MD[SUP]2[/SUP]; Tegan K. Boehmer, PhD, MPH[SUP]2[/SUP]; Nedra Y. Garret, MS[SUP]2[/SUP]; L. Charles Bailey, MD, PhD[SUP]4[/SUP]; Lindsay G. Cowell, MS, PhD[SUP]5[/SUP]; Christine Draper, BS[SUP]6[/SUP]; Kenneth H. Mayer, MD[SUP]7[/SUP]; Kshema Nagavedu, MPH[SUP]6[/SUP]; Jon E. Puro, MPA-HA[SUP]8[/SUP]; Sonja A. Rasmussen, MD, MS[SUP]9[/SUP]; William E. Trick, MD[SUP]10[/SUP]; Valentine Wanga, PhD[SUP]1,2[/SUP]; Jennifer R. Chevinsky, MD, MPH[SUP]1,2[/SUP]; Brendan R. Jackson, MD, MPH[SUP]2[/SUP]; Alyson B. Goodman, MD, MPH[SUP]2[/SUP]; Jennifer R. Cope, MD, MPH[SUP]2[/SUP]; Adi V. Gundlapalli, MD, PhD[SUP]2[/SUP]; Jason P. Block, MD, MPH[SUP]6[/SUP]
Author Affiliations Article Information
JAMA Netw Open. 2022;5(2):e2147053. doi:10.1001/jamanetworkopen.2021.47053
Key Points
Question Are select new symptoms and conditions more common among persons aged younger than 20 years and 20 years or older who tested positive for SARS-CoV-2 compared with those who tested negative?
Findings In this cohort study of 338 024 persons younger than 20 years and 1 790 886 persons 20 years or older who were tested for SARS-CoV-2, new diagnoses of shortness of breath, nonspecific heart rate abnormalities, and type 2 diabetes were more common among those hospitalized after positive compared with negative test results; fatigue was more common among those aged 20 years or older.
Meaning Given these findings, health care professionals should be aware of new symptoms and conditions that may develop after SARS-CoV-2 infection, particularly among those hospitalized.
Abstract
Importance New symptoms and conditions can develop following SARS-CoV-2 infection. Whether they occur more frequently among persons with SARS-CoV-2 infection compared with those without is unclear.
Objective To compare the prevalence of new diagnoses of select symptoms and conditions between 31 and 150 days after testing among persons who tested positive vs negative for SARS-CoV-2.
Design, Setting, and Participants This cohort study analyzed aggregated electronic health record data from 40 health care systems, including 338 024 persons younger than 20 years and 1 790 886 persons aged 20 years or older who were tested for SARS-CoV-2 during March to December 2020 and who had medical encounters between 31 and 150 days after testing.
Main Outcomes and Measures International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes were used to capture new symptoms and conditions that were recorded 31 to 150 days after a SARS-CoV-2 test but absent in the 18 months to 7 days prior to testing. The prevalence of new symptoms and conditions was compared between persons with positive and negative SARS-CoV-2 tests stratified by age (20 years or older and young than 20 years) and care setting (nonhospitalized, hospitalized, or hospitalized and ventilated).
Results A total of 168 701 persons aged 20 years or older and 26 665 younger than 20 years tested positive for SARS-CoV-2, and 1 622 185 persons aged 20 years or older and 311 359 younger than 20 years tested negative. Shortness of breath was more common among persons with a positive vs negative test result among hospitalized patients (≥20 years: prevalence ratio [PR], 1.89 [99% CI, 1.79-2.01]; <20 years: PR, 1.72 [99% CI, 1.17-2.51]). Shortness of breath was also more common among nonhospitalized patients aged 20 years or older with a positive vs negative test result (PR, 1.09 [99% CI, 1.05-1.13]). Among hospitalized persons aged 20 years or older, the prevalence of new fatigue (PR, 1.35 [99% CI, 1.27-1.44]) and type 2 diabetes (PR, 2.03 [99% CI, 1.87-2.19]) was higher among those with a positive vs a negative test result. Among hospitalized persons younger than 20 years, the prevalence of type 2 diabetes (PR, 2.14 [99% CI, 1.13-4.06]) was higher among those with a positive vs a negative test result; however, the prevalence difference was less than 1%.
Conclusions and Relevance In this cohort study, among persons hospitalized after a positive SARS-CoV-2 test result, diagnoses of certain symptoms and conditions were higher than among those with a negative test result. Health care professionals should be aware of symptoms and conditions that may develop after SARS-CoV-2 infection, particularly among those hospitalized after diagnosis.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788641
Public Health
February 4, 2022
Prevalence of Select New Symptoms and Conditions Among Persons Aged Younger Than 20 Years and 20 Years or Older at 31 to 150 Days After Testing Positive or Negative for SARS-CoV-2
Alfonso C. Hernandez-Romieu, MD, MPH[SUP]1,2[/SUP]; Thomas W. Carton, PhD, MS[SUP]3[/SUP]; Sharon Saydah, PhD[SUP]2[/SUP]; et alEduardo Azziz-Baumgartner, MD[SUP]2[/SUP]; Tegan K. Boehmer, PhD, MPH[SUP]2[/SUP]; Nedra Y. Garret, MS[SUP]2[/SUP]; L. Charles Bailey, MD, PhD[SUP]4[/SUP]; Lindsay G. Cowell, MS, PhD[SUP]5[/SUP]; Christine Draper, BS[SUP]6[/SUP]; Kenneth H. Mayer, MD[SUP]7[/SUP]; Kshema Nagavedu, MPH[SUP]6[/SUP]; Jon E. Puro, MPA-HA[SUP]8[/SUP]; Sonja A. Rasmussen, MD, MS[SUP]9[/SUP]; William E. Trick, MD[SUP]10[/SUP]; Valentine Wanga, PhD[SUP]1,2[/SUP]; Jennifer R. Chevinsky, MD, MPH[SUP]1,2[/SUP]; Brendan R. Jackson, MD, MPH[SUP]2[/SUP]; Alyson B. Goodman, MD, MPH[SUP]2[/SUP]; Jennifer R. Cope, MD, MPH[SUP]2[/SUP]; Adi V. Gundlapalli, MD, PhD[SUP]2[/SUP]; Jason P. Block, MD, MPH[SUP]6[/SUP]
Author Affiliations Article Information
JAMA Netw Open. 2022;5(2):e2147053. doi:10.1001/jamanetworkopen.2021.47053
Key Points
Question Are select new symptoms and conditions more common among persons aged younger than 20 years and 20 years or older who tested positive for SARS-CoV-2 compared with those who tested negative?
Findings In this cohort study of 338 024 persons younger than 20 years and 1 790 886 persons 20 years or older who were tested for SARS-CoV-2, new diagnoses of shortness of breath, nonspecific heart rate abnormalities, and type 2 diabetes were more common among those hospitalized after positive compared with negative test results; fatigue was more common among those aged 20 years or older.
Meaning Given these findings, health care professionals should be aware of new symptoms and conditions that may develop after SARS-CoV-2 infection, particularly among those hospitalized.
Abstract
Importance New symptoms and conditions can develop following SARS-CoV-2 infection. Whether they occur more frequently among persons with SARS-CoV-2 infection compared with those without is unclear.
Objective To compare the prevalence of new diagnoses of select symptoms and conditions between 31 and 150 days after testing among persons who tested positive vs negative for SARS-CoV-2.
Design, Setting, and Participants This cohort study analyzed aggregated electronic health record data from 40 health care systems, including 338 024 persons younger than 20 years and 1 790 886 persons aged 20 years or older who were tested for SARS-CoV-2 during March to December 2020 and who had medical encounters between 31 and 150 days after testing.
Main Outcomes and Measures International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes were used to capture new symptoms and conditions that were recorded 31 to 150 days after a SARS-CoV-2 test but absent in the 18 months to 7 days prior to testing. The prevalence of new symptoms and conditions was compared between persons with positive and negative SARS-CoV-2 tests stratified by age (20 years or older and young than 20 years) and care setting (nonhospitalized, hospitalized, or hospitalized and ventilated).
Results A total of 168 701 persons aged 20 years or older and 26 665 younger than 20 years tested positive for SARS-CoV-2, and 1 622 185 persons aged 20 years or older and 311 359 younger than 20 years tested negative. Shortness of breath was more common among persons with a positive vs negative test result among hospitalized patients (≥20 years: prevalence ratio [PR], 1.89 [99% CI, 1.79-2.01]; <20 years: PR, 1.72 [99% CI, 1.17-2.51]). Shortness of breath was also more common among nonhospitalized patients aged 20 years or older with a positive vs negative test result (PR, 1.09 [99% CI, 1.05-1.13]). Among hospitalized persons aged 20 years or older, the prevalence of new fatigue (PR, 1.35 [99% CI, 1.27-1.44]) and type 2 diabetes (PR, 2.03 [99% CI, 1.87-2.19]) was higher among those with a positive vs a negative test result. Among hospitalized persons younger than 20 years, the prevalence of type 2 diabetes (PR, 2.14 [99% CI, 1.13-4.06]) was higher among those with a positive vs a negative test result; however, the prevalence difference was less than 1%.
Conclusions and Relevance In this cohort study, among persons hospitalized after a positive SARS-CoV-2 test result, diagnoses of certain symptoms and conditions were higher than among those with a negative test result. Health care professionals should be aware of symptoms and conditions that may develop after SARS-CoV-2 infection, particularly among those hospitalized after diagnosis.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788641