Mary Wilson
Well-known member
November 1, 2021
doi: 10.1001/jama.2021.19623
Laith J. Abu-Raddad, PhD[SUP]1,2,3,4[/SUP]; Hiam Chemaitelly, MSc[SUP]1,2[/SUP]; Houssein H. Ayoub, PhD[SUP]5[/SUP]; et al
Key Points
Question
Are persons vaccinated after SARS-CoV-2 infection better protected against breakthrough infection than those vaccinated without prior infection?
Findings
In this cohort study of 1 531 736 mRNA-vaccinated individuals in Qatar, prior SARS-CoV-2 infection was associated with a statistically significant reduced hazard of breakthrough infection among recipients of both the BNT162b2 (Pfizer-BioNTech) (adjusted hazard ratio, 0.62) and the mRNA-1273 (Moderna) vaccines (adjusted hazard ratio, 0.40).
Meaning
Prior SARS-CoV-2 infection was associated with a lower risk for breakthrough infection among persons receiving the SARS-CoV-2 mRNA vaccines; however, the observational study design precludes direct comparison of infection risk between the 2 vaccines.
Abstract
Importance
The effect of prior SARS-CoV-2 infection on vaccine protection remains poorly understood.
Objective
To assess protection from SARS-CoV-2 breakthrough infection after mRNA vaccination among persons with vs without prior SARS-CoV-2 infection.
...
https://jamanetwork.com/journals/ja...m=social&utm_term=112021#.YZjpAP24g24.twitter
doi: 10.1001/jama.2021.19623
Laith J. Abu-Raddad, PhD[SUP]1,2,3,4[/SUP]; Hiam Chemaitelly, MSc[SUP]1,2[/SUP]; Houssein H. Ayoub, PhD[SUP]5[/SUP]; et al
Key Points
Question
Are persons vaccinated after SARS-CoV-2 infection better protected against breakthrough infection than those vaccinated without prior infection?
Findings
In this cohort study of 1 531 736 mRNA-vaccinated individuals in Qatar, prior SARS-CoV-2 infection was associated with a statistically significant reduced hazard of breakthrough infection among recipients of both the BNT162b2 (Pfizer-BioNTech) (adjusted hazard ratio, 0.62) and the mRNA-1273 (Moderna) vaccines (adjusted hazard ratio, 0.40).
Meaning
Prior SARS-CoV-2 infection was associated with a lower risk for breakthrough infection among persons receiving the SARS-CoV-2 mRNA vaccines; however, the observational study design precludes direct comparison of infection risk between the 2 vaccines.
Abstract
Importance
The effect of prior SARS-CoV-2 infection on vaccine protection remains poorly understood.
Objective
To assess protection from SARS-CoV-2 breakthrough infection after mRNA vaccination among persons with vs without prior SARS-CoV-2 infection.
...
https://jamanetwork.com/journals/ja...m=social&utm_term=112021#.YZjpAP24g24.twitter