tetano
Editor, Senior Moderator
[h=1]Sepsis and the Global Burden of Disease in Children[/h] Niranjan Kissoon, MD, FRCPC[SUP]1[/SUP]; Timothy M. Uyeki, MD, MPH, MPP[SUP]2[/SUP]
[+] Author Affiliations
JAMA Pediatr. Published online December 14, 2015. doi:10.1001/jamapediatrics.2015.3241
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This Viewpoint discusses the impact of sepsis on childhood mortality worldwide.
In 2010, an estimated 25% of disability-adjusted life-years?a metric that incorporates premature death by years of life lost and years lived with disability?and 13% of all deaths worldwide were in children younger than 5 years.[SUP]1[/SUP][SUP],2[/SUP] While reductions in mortality in children younger than 5 years have occurred in many countries since 1990, mortality increased in young children in some parts of sub-Saharan Africa, with severe infections leading to sepsis being a major contributor.[SUP]1[/SUP] For instance, in the neonatal period, diarrhea, lower respiratory tract infections, and meningitis were important contributors to mortality in 2010, while in the postneonatal period, nearly 1 million estimated deaths (half of all deaths) were due to lower respiratory tract infections (respiratory syncytial virus, Haemophilus influenzae type B, Streptococcus pneumoniae), diarrheal diseases (rotavirus, Cryptosporidium), and malaria.[SUP]2[/SUP] Other infectious causes of death in children younger than 5 years were measles, pertussis, and human immunodeficiency virus/AIDS. We suggest that sepsis-related pediatric deaths are substantially underestimated and that efforts are needed to better assess the impact of sepsis on childhood mortality worldwide.
http://archpedi.jamanetwork.com/article.aspx?articleid=2476189
[+] Author Affiliations
JAMA Pediatr. Published online December 14, 2015. doi:10.1001/jamapediatrics.2015.3241
Text Size: A A A
This Viewpoint discusses the impact of sepsis on childhood mortality worldwide.
In 2010, an estimated 25% of disability-adjusted life-years?a metric that incorporates premature death by years of life lost and years lived with disability?and 13% of all deaths worldwide were in children younger than 5 years.[SUP]1[/SUP][SUP],2[/SUP] While reductions in mortality in children younger than 5 years have occurred in many countries since 1990, mortality increased in young children in some parts of sub-Saharan Africa, with severe infections leading to sepsis being a major contributor.[SUP]1[/SUP] For instance, in the neonatal period, diarrhea, lower respiratory tract infections, and meningitis were important contributors to mortality in 2010, while in the postneonatal period, nearly 1 million estimated deaths (half of all deaths) were due to lower respiratory tract infections (respiratory syncytial virus, Haemophilus influenzae type B, Streptococcus pneumoniae), diarrheal diseases (rotavirus, Cryptosporidium), and malaria.[SUP]2[/SUP] Other infectious causes of death in children younger than 5 years were measles, pertussis, and human immunodeficiency virus/AIDS. We suggest that sepsis-related pediatric deaths are substantially underestimated and that efforts are needed to better assess the impact of sepsis on childhood mortality worldwide.
http://archpedi.jamanetwork.com/article.aspx?articleid=2476189