tetano
Editor, Senior Moderator
J Infect Dis. (2014) doi: 10.1093/infdis/jiu185 First published online: March 26, 2014
Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012
Jill M. Ferdinands1,2,
Lauren E.W. Olsho3,
Anna A. Agan4,
Niranjan Bhat5,
Ryan M. Sullivan4,
Mark Hall6,
Peter M. Mourani7,
Mark Thompson1,
Adrienne G. Randolph4,
on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
+ Author Affiliations
1Influenza Division, U.S. Centers for Disease Control and Prevention; Atlanta, GA
2Battelle Memorial Institute; Atlanta, GA
3Abt Associates, Inc.; Cambridge MA
4Department of Anesthesia, Perioperative and Pain Medicine (Critical Care), Boston Children's Hospital; Boston, MA
5Johns Hopkins Bloomberg School of Public Health; Baltimore, MD
6Division of Critical Care Medicine, Nationwide Children's Hospital; Columbus, OH
7Section of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado; Aurora, CO
Corresponding author: Jill Ferdinands, PhD, US Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A-20, Atlanta, GA 30333, Tel 404 639-2814, Fax 404 639-3866, jferdinands@cdc.gov
Abstract
Background. No studies have examined the effectiveness of influenza vaccine against ICU admission associated with influenza virus infection among children.
Methods. In 2010-11 and 2011-12, children aged 6 months to 17 years admitted to 21 US pediatric intensive care units (PICUs) with acute severe respiratory illness and testing positive for influenza were enrolled as cases; children who tested negative were PICU controls. Community controls were children without an influenza-related hospitalization, matched to cases by comorbidities and geographic region. Vaccine effectiveness was estimated with logistic regression models.
Results. We analyzed data from 44 cases, 172 PICU controls, and 93 community controls. Eighteen percent of cases, 31% of PICU controls, and 51% of community controls were fully vaccinated. Compared to unvaccinated children, children who were fully vaccinated were 74% (95% CI, 19 to 91%) or 82% (95% CI, 23 to 96%) less likely to be admitted to a PICU for influenza compared to PICU controls or community controls, respectively. Receipt of one dose of vaccine among children for whom two doses were recommended was not protective.
Conclusion. During the 2010-11 and 2011-12 US influenza seasons, influenza vaccination was associated with a three-quarters reduction in the risk of life-threatening influenza illness in children.
http://jid.oxfordjournals.org/content/early/2014/03/23/infdis.jiu185.abstract
Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012
Jill M. Ferdinands1,2,
Lauren E.W. Olsho3,
Anna A. Agan4,
Niranjan Bhat5,
Ryan M. Sullivan4,
Mark Hall6,
Peter M. Mourani7,
Mark Thompson1,
Adrienne G. Randolph4,
on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
+ Author Affiliations
1Influenza Division, U.S. Centers for Disease Control and Prevention; Atlanta, GA
2Battelle Memorial Institute; Atlanta, GA
3Abt Associates, Inc.; Cambridge MA
4Department of Anesthesia, Perioperative and Pain Medicine (Critical Care), Boston Children's Hospital; Boston, MA
5Johns Hopkins Bloomberg School of Public Health; Baltimore, MD
6Division of Critical Care Medicine, Nationwide Children's Hospital; Columbus, OH
7Section of Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado; Aurora, CO
Corresponding author: Jill Ferdinands, PhD, US Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A-20, Atlanta, GA 30333, Tel 404 639-2814, Fax 404 639-3866, jferdinands@cdc.gov
Abstract
Background. No studies have examined the effectiveness of influenza vaccine against ICU admission associated with influenza virus infection among children.
Methods. In 2010-11 and 2011-12, children aged 6 months to 17 years admitted to 21 US pediatric intensive care units (PICUs) with acute severe respiratory illness and testing positive for influenza were enrolled as cases; children who tested negative were PICU controls. Community controls were children without an influenza-related hospitalization, matched to cases by comorbidities and geographic region. Vaccine effectiveness was estimated with logistic regression models.
Results. We analyzed data from 44 cases, 172 PICU controls, and 93 community controls. Eighteen percent of cases, 31% of PICU controls, and 51% of community controls were fully vaccinated. Compared to unvaccinated children, children who were fully vaccinated were 74% (95% CI, 19 to 91%) or 82% (95% CI, 23 to 96%) less likely to be admitted to a PICU for influenza compared to PICU controls or community controls, respectively. Receipt of one dose of vaccine among children for whom two doses were recommended was not protective.
Conclusion. During the 2010-11 and 2011-12 US influenza seasons, influenza vaccination was associated with a three-quarters reduction in the risk of life-threatening influenza illness in children.
http://jid.oxfordjournals.org/content/early/2014/03/23/infdis.jiu185.abstract