tetano
Editor, Senior Moderator
Jpn J Infect Dis
. 2022 Feb 28.
doi: 10.7883/yoken.JJID.2021.844. Online ahead of print.
Genome Recombination between Delta and Alpha Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Tsuyoshi Sekizuka[SUP] 1 [/SUP], Kentaro Itokawa[SUP] 1 [/SUP], Masumichi Saito[SUP] 2 [/SUP], Michitsugu Shimatani[SUP] 3 [/SUP], Shutoku Matsuyama[SUP] 4 [/SUP], Hideki Hasegawa[SUP] 4 [/SUP], Tomoya Saito[SUP] 2 [/SUP], Makoto Kuroda[SUP] 1 [/SUP]
Affiliations
Abstract
Prominent genomic recombination has been observed between the Delta and Alpha variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from clinical specimens in Japan. Interestingly, the recombination variant detected in this study carries a spike protein identical to the one in the domestic Delta variant, thereby suggesting that further risks would not be concerned with infectivity and immune escape. The recombinant has been classified as XC lineage in the PANGOLIN database. It is necessary to intensively study such marked genetic variations and characterize the emerging variants after careful verification of their lineage and clade assignment.
Keywords: Alpha variant; Delta variant; Genome recombination; SARS-CoV-2.
. 2022 Feb 28.
doi: 10.7883/yoken.JJID.2021.844. Online ahead of print.
Genome Recombination between Delta and Alpha Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Tsuyoshi Sekizuka[SUP] 1 [/SUP], Kentaro Itokawa[SUP] 1 [/SUP], Masumichi Saito[SUP] 2 [/SUP], Michitsugu Shimatani[SUP] 3 [/SUP], Shutoku Matsuyama[SUP] 4 [/SUP], Hideki Hasegawa[SUP] 4 [/SUP], Tomoya Saito[SUP] 2 [/SUP], Makoto Kuroda[SUP] 1 [/SUP]
Affiliations
- PMID: 35228502
- DOI: 10.7883/yoken.JJID.2021.844
Abstract
Prominent genomic recombination has been observed between the Delta and Alpha variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from clinical specimens in Japan. Interestingly, the recombination variant detected in this study carries a spike protein identical to the one in the domestic Delta variant, thereby suggesting that further risks would not be concerned with infectivity and immune escape. The recombinant has been classified as XC lineage in the PANGOLIN database. It is necessary to intensively study such marked genetic variations and characterize the emerging variants after careful verification of their lineage and clade assignment.
Keywords: Alpha variant; Delta variant; Genome recombination; SARS-CoV-2.