tetano
Editor, Senior Moderator
Korean J Intern Med
. 2020 Jun 19.
doi: 10.3904/kjim.2020.203. Online ahead of print.
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Detection After Resolution of Coronavirus Disease 2019-associated symptoms/signs
Se Yoon Park[SUP] 1 [/SUP], Soon Gyu Yun[SUP] 2 [/SUP], Jeong Won Shin[SUP] 2 [/SUP], Bo Young Lee[SUP] 3 [/SUP], Hyo-Ju Son[SUP] 1 [/SUP], Seungjae Lee[SUP] 1 [/SUP], Eunjung Lee[SUP] 1 [/SUP], Tae Hyong Kim[SUP] 1 [/SUP]
Affiliations
Abstract
There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after remission of symptoms. We investigated the duration of SARS-CoV-2 RNA detection using real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 in nasopharyngeal/oropharyngeal swabs or sputum or saliva. Six patients were included in the final analysis. The median (range) duration of SARS-CoV-2 viral detection after hospitalization was 34 days (22 to 67). After resolution of symptoms/signs, SARS-CoV-2 RNA was detected for median (range) of 26 days (9 to 48). Among the six patients, one had persistent detection of SARS-CoV-2 RNA until day 67 of hospitalization, which was 30 days after symptom resolution. This case represents the longest duration of SARS-CoV-2 detection, and highlights the need for long-term follow up of COVID-19 patients despite resolution of symptoms to confirm SARS-CoV-2 clearance.
Keywords: COVID-19; Severe acute respiratory syndrome coronavirus 2; Virus shedding.
. 2020 Jun 19.
doi: 10.3904/kjim.2020.203. Online ahead of print.
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Detection After Resolution of Coronavirus Disease 2019-associated symptoms/signs
Se Yoon Park[SUP] 1 [/SUP], Soon Gyu Yun[SUP] 2 [/SUP], Jeong Won Shin[SUP] 2 [/SUP], Bo Young Lee[SUP] 3 [/SUP], Hyo-Ju Son[SUP] 1 [/SUP], Seungjae Lee[SUP] 1 [/SUP], Eunjung Lee[SUP] 1 [/SUP], Tae Hyong Kim[SUP] 1 [/SUP]
Affiliations
- PMID: 32549526
- DOI: 10.3904/kjim.2020.203
Abstract
There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after remission of symptoms. We investigated the duration of SARS-CoV-2 RNA detection using real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 in nasopharyngeal/oropharyngeal swabs or sputum or saliva. Six patients were included in the final analysis. The median (range) duration of SARS-CoV-2 viral detection after hospitalization was 34 days (22 to 67). After resolution of symptoms/signs, SARS-CoV-2 RNA was detected for median (range) of 26 days (9 to 48). Among the six patients, one had persistent detection of SARS-CoV-2 RNA until day 67 of hospitalization, which was 30 days after symptom resolution. This case represents the longest duration of SARS-CoV-2 detection, and highlights the need for long-term follow up of COVID-19 patients despite resolution of symptoms to confirm SARS-CoV-2 clearance.
Keywords: COVID-19; Severe acute respiratory syndrome coronavirus 2; Virus shedding.