tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2012 May 23. [Epub ahead of print]
Lack of interference with immunogenicity of a chimeric alphavirus replicon particle-based influenza vaccine by pre-existing anti-vector immunity.
Uematsu Y, Vajdy M, Lian Y, Perri S, Greer CE, Legg HS, Galli G, Saletti G, Otten GR, Rappuoli R, Barnett SW, Polo JM.
Source
Novartis Vaccines and Diagnostics S.r.l., Via Fiorentina, 1, 53100, Siena Italy.
Abstract
Anti-vector immunity has been recognized as a potential caveat of using virus based vaccines. In the present study, an alphavirus-based replicon particle vaccine platform, which has demonstrated robust immunogenicity in animal models, was tested for effects of anti-vector immunity on immunogenicity against hemagglutinin of influenza virus as a target antigen and efficacy for protection against lethal challenge with the virus. Chimeric alphavirus-based replicon particles, comprising Venezuelan equine encephalitis virus non-structural and Sindbis virus structural components, induced efficient protective antibody responses, which were not adversely influenced after multiple immunizations with the same vector expressing various antigens.
PMID:
22623651
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22623651
Lack of interference with immunogenicity of a chimeric alphavirus replicon particle-based influenza vaccine by pre-existing anti-vector immunity.
Uematsu Y, Vajdy M, Lian Y, Perri S, Greer CE, Legg HS, Galli G, Saletti G, Otten GR, Rappuoli R, Barnett SW, Polo JM.
Source
Novartis Vaccines and Diagnostics S.r.l., Via Fiorentina, 1, 53100, Siena Italy.
Abstract
Anti-vector immunity has been recognized as a potential caveat of using virus based vaccines. In the present study, an alphavirus-based replicon particle vaccine platform, which has demonstrated robust immunogenicity in animal models, was tested for effects of anti-vector immunity on immunogenicity against hemagglutinin of influenza virus as a target antigen and efficacy for protection against lethal challenge with the virus. Chimeric alphavirus-based replicon particles, comprising Venezuelan equine encephalitis virus non-structural and Sindbis virus structural components, induced efficient protective antibody responses, which were not adversely influenced after multiple immunizations with the same vector expressing various antigens.
PMID:
22623651
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22623651