tetano
Editor, Senior Moderator
J Card Fail. 2013 Dec 18. pii: S1071-9164(13)01280-3. doi: 10.1016/j.cardfail.2013.12.008. [Epub ahead of print]
Lack of Persistence of Influenza Vaccine Antibody Titers in Patients with Heart Failure.
Albrecht CM1, Sweitzer NK2, Johnson MR2, Vardeny O3.
Author information
Abstract
BACKGROUND:
Patients with heart failure (HF) have lower initial antibody responses to the influenza vaccine compared to healthy individuals. Whether antibody titers wane faster in this population remains unknown.
METHODS AND RESULTS:
We studied 62 HF patients (18 ischemic, 44 idiopathic) and 40 healthy controls (HC) during the 2006/2007 and 2007/2008 influenza seasons. Antibody titers were measured before, and 2-4 weeks, and 11-12 months after vaccination. Serum antibody production was measured by hemagglutination inhibition assay, and antibody titers to individual vaccine viral strains between HF and HC were compared following the influenza season to measure persistence of antibody response. All participants demonstrated early antibody seroprotection (titers 40 hemmaglutination inhibition units [HAU] to 1 strain). While antibody titers waned over time in both groups, titers to A/H3N2 and A/H1N1 strains decreased more in HF participants compared to HC (p=0.004 and p=0.04, respectively). Titers to the B-type strain decreased to below seroprotective levels in both groups.
CONCLUSIONS:
Antibody titers to influenza A vaccine strains wane to below seroprotective levels in HF patients compared to HC, despite similar rates of initial seroprotection and seroconversion. These findings suggest that HF patients may remain at increased risk for influenza infection despite annual vaccination.
Copyright ? 2013 Elsevier Inc. All rights reserved.
KEYWORDS:
Influenza, antibodies INTRODUCTION, vaccine
PMID:
24361852
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24361852
Lack of Persistence of Influenza Vaccine Antibody Titers in Patients with Heart Failure.
Albrecht CM1, Sweitzer NK2, Johnson MR2, Vardeny O3.
Author information
Abstract
BACKGROUND:
Patients with heart failure (HF) have lower initial antibody responses to the influenza vaccine compared to healthy individuals. Whether antibody titers wane faster in this population remains unknown.
METHODS AND RESULTS:
We studied 62 HF patients (18 ischemic, 44 idiopathic) and 40 healthy controls (HC) during the 2006/2007 and 2007/2008 influenza seasons. Antibody titers were measured before, and 2-4 weeks, and 11-12 months after vaccination. Serum antibody production was measured by hemagglutination inhibition assay, and antibody titers to individual vaccine viral strains between HF and HC were compared following the influenza season to measure persistence of antibody response. All participants demonstrated early antibody seroprotection (titers 40 hemmaglutination inhibition units [HAU] to 1 strain). While antibody titers waned over time in both groups, titers to A/H3N2 and A/H1N1 strains decreased more in HF participants compared to HC (p=0.004 and p=0.04, respectively). Titers to the B-type strain decreased to below seroprotective levels in both groups.
CONCLUSIONS:
Antibody titers to influenza A vaccine strains wane to below seroprotective levels in HF patients compared to HC, despite similar rates of initial seroprotection and seroconversion. These findings suggest that HF patients may remain at increased risk for influenza infection despite annual vaccination.
Copyright ? 2013 Elsevier Inc. All rights reserved.
KEYWORDS:
Influenza, antibodies INTRODUCTION, vaccine
PMID:
24361852
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24361852